CAS: 161552-03-0; 2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-Benzyl-11-(3-Guanidinopropyl)-3,6,9,12,15-Pentaoxo-1,4,7,10,13-Pentaazacyclopentadecan-2-yl)Acetic Acid

上下游产品

45H67N9O10SC45H67N9O10S Fm°C-(tBu)Asp-OH Fm°C-D-Phe-OH All°C-L-Lys(N-Fm°C)-OH73H111N23O22C73H111N23O22

在 Palladium 10% On Activated Carbon,氢气体系中,用 甲醇,溶剂黄146 用作溶剂,化学反应 18.0H,以100%的收率获得环(-Rgdfk)
参考文献:通过微流肽链延长和光化学环化 的快速清洁合成方法来合成环肽:环状rgd肽的合成†
标题:通过微流肽链延长和光化学环化 的快速清洁合成方法来合成环肽:环状rgd肽的合成†
摘要:环状rgd肽有效地合成基于微流,三光气介导的肽链延长和微流光化学大内酰胺化.我们的方法可以快速合成环状肽(酰胺化<5 S,大内酰胺化<5 Min),并且可以清洁合成(仅一柱色谱分离).
Doi:10.1039/c6Ob02391F

专利信息

专利号:US-7531622-B2
优先权日:2002-09-19
标 题:Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells
发明人：DUMY PASCAL; FAVROT MARIE-CHRISTINE; BOTURYN DIDIER; COLL JEAN-LUC
权利人:CENTRE NAT RECH SCIENT; UNIV JOSEPH FOURIER; INST NAT SANTE RECH MED
摘要:A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.

专利号:US-2006173160-A1
优先权日:2002-09-19
标 题:Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells

专利号:EP-1539804-A2
优先权日:2002-09-19
标题:Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells

专利号:CA-2499496-C
优先权日:2002-09-19
标题 :Synthesis and characterization of novel systems for guidance and vectorization of compounds having a therapeutic activity

专利号:WO-2004026894-A2
优先权日:2002-09-19
标题:Synthesis and characterization of novel systems for guidance and vectorization of compounds having a therapeutic activity

专利号:JP-2006514919-A
优先权日:2002-09-19
标题:Synthesis and characterization of novel induction systems and vectorization of therapeutic molecules into target cells