CAS: 1644545-52-7; 6-(6-Chloropyridin-2-yl)-N2,N4-Bis((R)-1,1,1-Trifluoropropan-2-yl)-1,3,5-Triazine-2,4-Diamine

上下游产品

2,4-二氯-6-(6-氯-2-吡啶基)-1,3,5-三嗪 2,4-Dichloro-6-(6-Chloropyridin-2-yl)-1,3,5-Triazine 1446507-39-6

6-氯-2-吡啶羧酸甲酯置于苄基三乙基氯化铵,N,N-二异丙基乙胺,三氯氧磷体系中,用 N-甲基吡咯烷酮,乙醇 用作溶剂,化学反应 2.0H,反应生成Pvm/ma共聚物
参考文献: Cocrystals,Pharmaceutical Compositions Thereof,And Methods Of Treatment Involving Same[fr] Cocristaux,Compositions Pharmaceutiques De Ceux-Ci,Et Méthodes De Traitement Les Impliquant
标题: Cocrystals,Pharmaceutical Compositions Thereof,And Methods Of Treatment Involving Same[fr] Cocristaux,Compositions Pharmaceutiques De Ceux-Ci,Et Méthodes De Traitement Les Impliquant
摘要:提供了一种固体形式的化合物,用于治疗癌症,以及相应的药物组合物,以及治疗癌症的方法,包括向需要的患者施用本文描述的固体形式.

专利信息

专利号:EP-3686190-A1
优先权日:2013-07-11
标 题 :Synthesis of therapeutically active compounds

专利号:US-11117906-B2
优先权日:2018-12-21
标题:Methods for synthesizing zinc-lysine-chloride complex
发明人：HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI; EVANS LAUREN; LEITE SERGIO
权利人:COLGATE PALMOLIVE CO
摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

专利号:US-11091502-B2
优先权日:2018-12-21
标 题:Methods for synthesizing zinc-lysine-chloride complex
发明人：HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI
权利人:COLGATE PALMOLIVE CO
摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

专利号:WO-2023144235-A1
优先权日:2022-01-27
标 题 :Methods for monitoring and treating warburg effect in patients with pi3k-related disorders
发明人：CANAUD GUILLAUME; LADRAA SOPHIA
权利人:INST NAT SANTE RECH MED; ASSIST PUBLIQUE HOPITAUX PARIS APHP; CENTRE NAT RECH SCIENT; UNIV PARIS CITE
摘要:Using a unique tool of PROS, they demonstrate that PIK3CA mutation leads to GLUT4 membrane accumulation with a negative feedback loop on insulin secretion, a burst of liver IGFBP1 synthesis with IGF1 sequestration and low circulating levels. They further show that AKT2 drives a large part of the phenotype. In addition, they demonstrate for the first time that a single PIK3CA mutation induces metabolic reprogramming with the Warburg effect and protein and lipid synthesis—hallmarks of cancer cells—in vitro, in vivo and in patients. They finally show that alpelisib, an approved PIK3CA inhibitor in oncology, is efficient at preventing and improving PIK3CA-adipose tissue overgrowth and reversing metabolomic anomalies in both animal models and patients. Accordingly, the present invention relates to an in vitro method for monitoring the efficiency of a PI3K inhibitor treatment in a subject in need thereof comprising the step of determining the level of at least one metabolite selected in the group consisting of cis-aconitate, succinic acid, 5-methylcytosine, acetyl-carnitine, acetyl-lysine, argininosuccinate, betaine, butyric acid, carnitine, creatine, glucose, glycine, hexanoyl-carnitine, L-fucose, lactate, L-dihydroorotic acid, linolenic acid, nicotinamide N-oxide, palmitoyl-carnitine, panthotenate, pyruvate, quinolinic acid, tryptophan, urate, in a biological sample obtained from the subject.

专利号:US-7427690-B2
优先权日:2004-06-05
标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration
发明人：GUPTA SHYAM K
权利人:BIODERM RESEARCH
摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.