3,3-二乙氧基丙酰胺置于phosphorus Pentoxide,三乙胺,苯体系中,化学反应生成氰基乙醛缩二乙醇 参考文献:Clinical Applications Of Serum Placental Protein 14 (Pp14) Measurement In The Ivf-Et Cycle 标题:Clinical Applications Of Serum Placental Protein 14 (Pp14) Measurement In The Ivf-Et Cycle 摘要:Abstractobjective: Placental Protein 14 (Pp14) Is Known To Be One Of The Endometrial Proteins That Reflect Endometrial Functioning Throughout The Menstrual Cycle. In This Study,We Examined Pp14 As A Marker For Human Endometrial Receptivity In Order To Predict The Outcome Of In Vitro Fertilization And The Embryo‐transfer (Ivf‐et) Cycle.Patients And Methods: The Subjects Were 72 Women Who Had 96 Ivf‐et Cycles And Who Were Examined At Tokyo Medical University Hospital During The Period Of January 1998 To June 1998 Because Of Mechanical Or Unexplained Infertility For A Duration Of At Least 2 Years. Serum Samples Were Collected From All Patients During Treatment Cycles,And Serum Ppi4 Concentrations Were Measured By A Newly Established Enzyme‐linked Immunosorbent Assay (Elisa).Results: In The Pregnant Group,Serum Pp14 Concentrations Were Markedly Increased After Et,And A Significant Difference Between The Pregnant Group And The Nonpregnant Group Was Observed 8 Days Following Et (P < 0.01). Pp14 Concentrations Were Higher In Patients With Endometria That Exhibited Homogenous Patterns And That Were More Than 7 Mm Thicker Than In Other Patients,As Determined By Ultrasound On The Day Of Oocyte Collection (P < 0.005). The Pregnancy Rates Of Patients With Homogeneous Patterns Were Lower Than Those Of Patients Showing A Trilaminar Pattern. No Pregnancies Were Observed When Serum Pp14 Concentrations Were Greater Than 6.85 U/l On The Day Of Oocyte Collection.Conclusion: Pp14 Might Be A Useful Marker For Human Endometrial Receptivity To Predict The Outcome Of Ivf‐et Cycles. Doi:10.1111/j.1447-0756.2000.Tb01325.X
专利号:US-4536599-A 优先权日:1978-08-22 标题:Synthesis of amine derivatives 发明人:MASUKO FUJIO; KATSURA TADASHI 权利人:SUMITOMO CHEMICAL CO 摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.
专利号:EP-0040896-B1 优先权日:1978-08-22 标题:Synthesis of amides
专利号:EP-0008532-A1 优先权日:1978-08-22 标 题 :Synthesis of amines
专利号:EP-0040896-A2 优先权日:1978-08-22 标 题 :Synthesis of amides
专利号:CN-109912454-B 优先权日:2019-03-26 标题 :Synthesis method of mixture of 3-ethoxyacrylonitrile and 3, 3-diethoxypropionitrile
专利号:CN-118221594-B 优先权日:2024-03-25 标 题 :Synthesis method of diaminopyrimidine nitrogen oxide
[参考文献]: Barbara Heller, Et Al. Photocatalyzed [2 + 2 + 2]-Cycloaddition Of Nitriles With Acetylene: An Effective Method For The Synthesis Of 2-Pyridines Under Mild Conditions. J Org Chem. 2002 Jun 28;67(13):4414-22.
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2014). 摘要:Sartori, G.; Maggi, R., Science of Synthesis, (2005) 18, 671. 摘要:von Angerer, S.; Warriner, S. L., Science of Synthesis, (2007) 29, 370.