CAS: 298-96-4; 2,3,5-Triphenyl-2H-Tetrazol-3-Ium Chloride

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CAS号531-52-2 1,3,5-三苯基甲臜 | CAS号507-40-4 次氨酸叔丁基酯 | CAS号128-09-6 N-氯代丁二酰亚胺 | CAS号3481-09-2 N-氯代酞酰亚胺 | CAS号7647-01-0 盐酸 | CAS号110-46-3 亚硝酸异戊酯 | CAS号588-64-7 苯甲醛苯腙 | CAS号531-52-2 1,3,5-三苯基甲臜

1,3,5-三苯甲置于n-氯代丁二酰亚胺体系中,用 二氯甲烷,水 用作溶剂,化学反应 5.0H,以90%的收率获得2,3,5-三苯基氯化四氮唑
参考文献:铜路易斯酸表面活性剂催化制备氯化-3-取 代-2,5-二苯基四氮唑的方法
标题:铜路易斯酸表面活性剂催化制备氯化-3-取 代-2,5-二苯基四氮唑的方法
摘要:本发明属于有机合成技术领域,具体涉及一种以铜路易斯酸表面活性剂为催化剂制备氯化‑3‑取代‑2,5‑二苯基四氮唑类化合物的方法,其包括以下步骤:1)以铜路易斯酸表面活性剂cu(Oso2Cnh2N+1)2为催化剂,苯甲醛,苯肼,芳香基胺和亚硝酸钠在溶剂水中反应得到3‑芳香基‑2,5‑二苯基甲臜;2)3‑芳香基‑2,5‑二苯基甲臜在二氯甲烷和水的混合溶剂中,在固体氯化试剂n‑氯代丁二酰亚胺的条件下进行关环和氯化,得到氯化‑3‑芳香基‑2,5‑二苯基四氮唑.该方法以"一锅法"连续的策略完成三步转化,不仅省略了中间的分离步骤,而且提纯步骤简单,简便易操作.

专利信息

专利号:US-6849743-B2
优先权日:1997-08-15
标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
发明人：SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
权利人:MILLENNIUM PHARM INC
摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

专利号:US-2024101632-A1
优先权日:2021-01-27
标 题:Genetically engineered electrically-stimulated effector cells for in situ synthesis of proteins
发明人：BHATNAGAR PARIJAT; NEWMYER SHERRI
权利人:STANFORD RES INST INT
摘要:An example genetically engineered electrically-stimulated (ES) cell comprises an exogenous polynucleotide sequence that includes an electrical-sensor element, an actuator element, and an effector element. The electrical-sensor element encodes a voltage-gated calcium ion channel (CaV), wherein the CaV is configured to transition from a closed state to an open state in response to stimulation. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein, wherein, in response to the transition of the CaV to the open state, the genetically engineered ES effector cell is configured to activate and, to synthesize and secrete the effector protein.

专利号:WO-0136626-A9
优先权日:1999-11-15
标 题 :Pentraxin i and pentraxin receptor, inhibitors of said proteins and pharmaceutical compositions containing said compounds
发明人：MESSEGUER PEYPOCH RAMON; ROSELL VIVES ELISABET; MARTINEZ ESCOLA JOSEP MA; RODES GUBERN BLANCA; ADAN PLANA JAUME; PUIG CALVO NURIA; CARCELLER ROSA ANA; MASA ALVAREZ MARC; PIULATS XANCO JAUME; DEN DAAS IZAAK; TRULLAS OLIVA RAMON; DE GREGORIO-ROCASOLANO BARBANY
权利人:MERCK PATENT GMBH; MESSEGUER PEYPOCH RAMON; ROSELL VIVES ELISABET; MARTINEZ ESCOLA JOSEP MA; RODES GUBERN BLANCA; ADAN PLANA JAUME; PUIG CALVO NURIA; CARCELLER ROSA ANA; MASA ALVAREZ MARC; PIULATS XANCO JAUME; DEN DAAS IZAAK; TRULLAS OLIVA RAMON; DE GREGORIO-ROCASOLANO BARBANY
摘要:Described are nucleic acid sequences encoding the human Pentraxin receptor and related proteins and pharmaceutical composition comprising a therapeutically effective amount of (a) Pentraxin I or the human Pentraxin receptor, (b) a nonfunctional variant of the protein of (a), (c) an antibody to the protein of (a) or (b), (d) a nucleic acid sequence encoding the protein of (a) or (b), (e) an antisense RNA sequence, said sequence being capable of inhibiting the synthesis of Pentraxin 1 or the human Pentraxin receptor, or (f) a ribozyme characterized in that it is complementary to a Pentraxin I or human Pentraxin receptor mRNA and can selectively bind to and cleave said mRNA, thus inhibiting the synthesis of Pentraxin I or the human Pentraxin receptor.

专利号:US-4980428-A
优先权日:1989-10-20
标 题 :Epoxy vinyl ethers and synthesis of an epoxy vinyl ether from a hydroxylated vinyl ether and a polyepoxide
发明人：LIU KOU-CHANG; VARA FULVIO J; DOUGHERTY JAMES A
权利人:GAF CHEMICALS CORP
摘要:This invention relates to epoxy vinyl ethers having the formula: ##STR1## wherein R is a polyvalent linear, branched or cyclic hydrocarbon radical having from 2 to 20 carbon atoms, optionally substituted with alkylenoxy; n has a value of from 1 to 20; p has a value of from 1 to 6; and at least one of Y and Y' is ##STR2## which any remaining Y and Y' can be ##STR3## The invention also relates to the synthesis and uses of the above polyphenyl vinyl ethers.

专利号:US-2024368164-A1
优先权日:2021-04-28
标 题 :Purine nucleosides, their intermediates, and methods of preparation thereof
发明人：RAVI RAMA SURESH; JACOBSON KENNETH A; POE RUSSELL BIRCH
权利人:ASTROCYLE PHARMACEUTICALS INC; US HEALTH
摘要:The present invention provides purine nucleoside analog compounds and methods of use thereof for treatment of certain injuries, disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. The present invention further provides methods of synthesizing such compounds, and intermediates useful in the synthesis of such compounds.

专利号:US-2017204442-A1
优先权日:2014-05-29
标题 :Enzymatic synthesis of soluble glucan fiber
发明人：DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.