CAS: 306-08-1; 2-(4-Hydroxy-3-Methoxyphenyl)Acetic Acid

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CAS号60563-13-5 高香兰酸乙酯 | CAS号55-10-7 3-甲氧基-4-羟基扁桃酸 | CAS号4468-59-1 3-甲氧基-4-羟基苯乙腈 | CAS号69638-06-8 2-溴-1-(4-羟基-3-甲... | CAS号498-02-2 香草乙酮 | CAS号5438-51-7 吡嗪-2-羧酸甲酯 | CAS号29973-91-9 4-苄氧基-3-甲氧基苯乙酸 | CAS号16209-54-4 methyl 4-benzyl... | CAS号107512-66-3 N-cyclo°Ctyl-2-... | CAS号38339-06-9 高香草酸硫酸盐 | CAS号60563-13-5 高香兰酸乙酯 | CAS号5447-38-1 4-乙酰基-3-甲氧基苯乙酸 | CAS号21913-98-4 3'-甲氧基大豆黄素 | CAS号289903-41-9 [2-[(4-tert-but... | CAS号93-40-3 3,4-二甲氧基苯乙酸 | CAS号15964-80-4 2-(4-羟基-3-甲氧基苯基)乙酸甲酯 | CAS号102-32-9 3,4-二羟基苯乙酸 | CAS号74-87-3 氯甲烷

γ-O-(4-Hydroxy-3-Methoxyphenacetyl) T-Butyl N-T-Boc L-Glutamate置于水,三氟乙酸体系中,化学反应 4.0H,反应生成 高香草酸
参考文献:新的光触发:扩展了对羟基苯甲酰pi-Pi的吸收范围.
标题:新的光触发:扩展了对羟基苯甲酰pi-Pi的吸收范围.
摘要:[等式-见正文]研发了用两种兴奋性γ-氨基酸(l-谷氨酸和γ-氨基丁酸)在4-羟基苯甲酰基(php)可光除去的保护基上引入3-甲氧基或3,5-二甲氧基取代基的方法. (gaba).这些取代基显着扩展了php发色团的吸收范围,例如2A,B的吸收带的尾部延伸超过400 Nm,远远超出了芳香族氨基酸和核苷酸的吸收.辐照释放出氨基酸的速率常数约为10(7)s(-)(1),外观效率(phi(app))为0.03-0.04.光产物是通过php激发三重态形成的,主要是光还原和光水解的产物.1A,B也重新排列为苯乙酸3.
DOI:10.1021/ol005856N

专利信息

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-9809522-B2
优先权日:2015-09-11
标 题 :Selective liquefaction of lignin and biomass in a mixture of sub- and supercritical fluids in absence or presence of heterogeneous catalysts
发明人：SMIRNOVA ALEVTINA; LYNDE CHRIS; Numan-Al-Mobin Abu Md; RAJAPPAGOWDA RUDRESH BOMMADIHALLI
权利人:SOUTH DAKOTA BOARD OF REGENTS
摘要:Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.

专利号:US-8420850-B2
优先权日:2010-05-14
标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
发明人：DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

专利号:US-5679773-A
优先权日:1995-01-17
标题 :Reagants and methods for immobilized polymer synthesis and display
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.

专利号:US-2004101523-A1
优先权日:1989-07-27
标题:Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension
发明人：REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J
权利人:SEARLE & CO
摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as dopa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitor compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-γ-glutamyl fusaric acid hydrazide (shown below) is preferred.