CAS: 5300-03-8; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-yl)Nona-2,4,6,8-Tetraenoic Acid

上下游产品

(2Z,4E,6Z,8E)-3,7-二甲基-9-(2,6,6-三甲基-1-环己烯基)壬-2,4,6,8-四烯酸 9,13-Di-Cis-Retinoic Acid 5352-74-9
维a酸 All-Trans-Retinoic-Acid 302-79-4
异维a酸 13-Cis-Retinoic Acid 4759-48-2
2,4-戊二烯酸,3-甲基-5-(2,6,6-三甲基-1-环己烯-1-基)-,(Z,E)- (2Z,4E)-3-Methyl-5-(2',6',6'-Trimethylcyclohex-1'-En-1'-yl)-2,4-Pentadienoic Acid 14398-44-8
9-顺式-维甲酸甲基酯 [7T,9C,11T,13T]Retinoic Acid Methyl Ester 58526-50-4
9-Cis-β-Jonyliden-Essigsaeuremethylester 20110-08-1
Methyl (2E,4Z,6E)-5-Methyl-7-(2,6,6-Trimethylcyclohexen-1-yl)Hepta-2,4,6-Trienoate 14398-59-5
9-顺式视黄醇 9-Cis-Retinol 22737-97-9
9-Cis,13-Cis-Retinal 23790-80-9
维生素a Retinol 68-26-8

9-顺式视黄醇置于manganese(Iv) Oxide,Sodium Hydroxide,Silver(L) Oxide体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,以72%的收率获得产物9-顺式维甲酸
参考文献:周环级联的9-顺式维甲酸立体控制合成
标题:周环级联的9-顺式维甲酸立体控制合成
摘要:据认为,本质上是环周的多米诺反应是在用芳基亚磺酰氯处理链烯醇10时引发的.该过程包括一个σ序的重排的有序序列:可逆的[2,3]-烯丙基亚磺酸盐向烯丙基亚砜的转变,然后是[2,3]-炔丙基亚磺酸盐向烯丙基亚砜的重排,最后是立体分化[1,5].-σ氢迁移导致多烯13.标记实验已证明c7至c11氢迁移的发生.据认为,[1,5]-σ氢位移的双非对映选择性是最终多烯13的单一异构体,这是由于亚砜在一个末端的电子效应和庞大的空间效应共同产生的在另一个末端有三甲基环己烯基取代基.因此,整个过程构成了由烯醛醇,特别是在共轭多烯侧链上具有7E,9Z,11Z,13E构型的类维生素a的e,Z,Z-三烯片段的立体选择性合成.这种方法在类维生素a(包括标记类似物)的合成中的应用很简单.
DOI:10.1021/jo991757F

专利信息

专利号:WO-9532946-A1
优先权日:1994-05-27
标题 :Methods for the synthesis of 9-cis retinoids and their novel intermediates
发明人：BENNANI YOUSSEF L
权利人:LIGAND PHARM INC
摘要:Methods for the synthesis of 9-cis retinoids, novel intermediates and methods for the synthesis of cyclohexadienyne nitriles and 9-cis alkyl cisoid nitriles, as well as 9-cis retinoids made using such methods are provided.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-5817845-A
优先权日:1993-04-21
标题:Methods for stereospecific synthesis of 11,13-cis polyene esters
发明人：WHITE STEVEN K; HWANG CHAN KOU; WINN DAVID T
权利人:LIGAND PHARM INC
摘要:Methods for stereospecific synthesis of 9-cis olefins and retinoids. In one particular aspect, a cis olefin is generated via a lactol ring opening with complete retention of double bond configuration.

专利号:US-6287818-B1
优先权日:2000-04-25
标 题 :Method for synthesis of N-homocysteine thiolactonyl retinamido cobalamin and uses thereof
发明人：KAZIMIR MICHAL; WILSON II F RAY
权利人:UNIV BAYLOR
摘要:The present invention describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.