CAS: 583-71-1; 4-Bromo-1,2-Dimethylbenzene

上下游产品

CAS号95-47-6 邻二甲苯 | CAS号593-53-3 氟甲烷 | CAS号106-38-7 对溴甲苯 | CAS号95-64-7 3,4-二甲基苯胺 | CAS号618-01-9 3, 4-二甲基苯磺酸 | CAS号7726-95-6 溴素 | CAS号7553-56-2 碘 | CAS号63114-76-1 2,3-dimethyl-N-... | CAS号105336-21-8 3,4-dimethyl-N-... | CAS号103323-56-4 4-(2-bromoethyl... | CAS号105336-41-2 N,N-dibutyl-3,4... | CAS号105336-40-1 N,N-dibutyl-2,3... | CAS号4920-95-0 3,3',4,4'-四甲基联苯 | CAS号38404-42-1 3,4-二甲基苯甲酸甲酯 | CAS号55499-43-9 3,4-二甲基苯硼酸 | CAS号55389-75-8 双(3,4-二甲基苯基)胺 | CAS号95-65-8 3,4-二甲酚

邻二甲苯置于n-溴代丁二酰亚胺(Nbs)体系中,用 水 作为反应溶剂,化学反应 0.67H,以55%的收率获得产物4-溴-1,2-二甲苯
参考文献:N-溴代琥珀酰亚胺在取代烷基芳烃的超声和微波辅助溴化反应中的化学选择性不同
标题:N-溴代琥珀酰亚胺在取代烷基芳烃的超声和微波辅助溴化反应中的化学选择性不同
摘要:各种烷基芳基与n-溴丁二酰亚胺在纯净或水中的超声和微波辅助溴化反应显示出不同的化学选择性.因此,在超声波作用下,水中发生环取代,而在微波作用下,侧链α-溴化和环取代都发生.对于纯净的反应物,微波辅助反应中侧链α-溴化反应占主导地位.在水的存在下,微波促进的溴化的化学选择性类似于使用传统方法观测到的化学选择性.
DOI:10.1016/j.Tetlet.2007.03.023

专利信息

专利号:US-8779122-B2
优先权日:2012-11-08
标 题:Process for the synthesis of (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:WO-2022114333-A1
优先权日:2020-11-30
标题:Method for efficient production of 2-[18f]fluoro-4-boronophenylalanine comprising radioisotopes
发明人：LEE SANG-YOON; KIM WOO KYUNG; CHUNG JUN-YOUNG; IDO TATSUO; LEE JIHYE; ALAM MOHAMMAD MAQUSOOD; LEE HAKJEONG
权利人:UNIV GACHON IND ACAD COOP FOUND; GIL MEDICAL CT
摘要:Disclosed is a method for producing of 2-[18F]fluoro-4-boronophenylalanine comprising radioisotopes ([18F]FBPA), the method having a precursor with an effective leaving group and reaction conditions for high-yield synthesis of [18F]FBPA to allow the target compound, [18F]FBPA, to be efficiently synthesized, and same can be mass produced using automated synthesis apparatuses to allow effective use in molecular imaging technology.

专利号:WO-2011106986-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
权利人:MERCK SHARP & DOHME; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
摘要:Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R 30 , R 40 , R 50 and R 60 of compounds of formula (I) are herein defined as in the description.

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.

专利号:US-6891069-B1
优先权日:2004-01-30
标 题:Synthesis of 4-substituted phthalaldehyde
发明人：ZHU PETER C; WANG DER-HAW
权利人:ETHICON INC
摘要:Disclosed herein are methods of synthesizing a 4-substituted-benzene-1,2-carbaldehyde. In one aspect, a method may include reacting a 4-substituted-1,2-bis(dibromomethyl) benzene with sulfuric acid to form a reaction product, introducing a solid sodium bicarbonate into the reaction product, and hydrolyzing the reaction product to form a 4-substituted-benzene-1,2-carbaldehyde, after introducing the bicarbonate.