CAS: 618-48-4; 3-Chlorobenzamide

该化合物是一种氯化芳烃,配有分子式C7H6ClNO.这种白色到白外晶体固体主要用作有机合成的中间体,特别是在制药,农用化学品和特殊化学品的生产中.其主要优点包括高纯度(>98%),标准条件下的稳定性和作为进一步功能化的构件的回动性.一种氨基体和一种氯替代成分存在于苯环上,可以用于核细胞替代和凝聚反应的多种用途.它可溶于普通有机溶剂,便于在实验室和工业过程中使用.建议适当的处理和储存,因为其潜在的刺激性能.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号587-04-2 3-氯苯甲醛 | CAS号766-84-7 3-氯苯腈 | CAS号4152-90-3 间氯苄胺 | CAS号1878-65-5 3-氯苯乙酸 | CAS号34158-71-9 (NZ)-N-[(3-chlo... | CAS号535-80-8 间氯苯甲酸 | CAS号873-63-2 3-氯苄醇 | CAS号16273-37-3 3-氯扁桃酸 | CAS号3717-33-7 (Z)-3-Chloroben... | CAS号106380-90-9 3-phenylsulfany... | CAS号40763-96-0 5-氯-2-硝基苯甲酰胺 | CAS号41421-28-7 5-(3-氯苯基)-1H-四唑 | CAS号587-04-2 3-氯苯甲醛 | CAS号873-63-2 3-氯苄醇 | CAS号188665-74-9 3-氨基甲酰苯硼酸频呢醇酯 | CAS号766-84-7 3-氯苯腈 | CAS号108-42-9 间氯苯胺 | CAS号2548-79-0 3-氯苯硫酰胺 | CAS号74703-17-6 3-chlorobenzoyl...

合成工艺路线路线简述

    3-硫苯甲酸置于ammonium Hydroxide,五氯化磷体系中,化学反应生成 间氯苯甲酰胺
    参考文献:Limpricht; V. Uslar,Justus Liebigs Annalen Der Chemie,1857,Vol. 102,P. 264
    标题:Limpricht; V. Uslar,Justus Liebigs Annalen Der Chemie,1857,Vol. 102,P. 264

    海关参考信息

    专利信息


    专利号:US-4161609-A
    优先权日:1977-09-14
    标题:Synthesis of carboxylic acid esters
    发明人:CRAMER RICHARD D
    权利人:DU PONT
    摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.

    专利号:US-5021444-A
    优先权日:1986-01-28
    标题 :Thianaphthene derivatives
    发明人:TRADA ATSUSUKE; AMEMIYA YOSHIYA; MATSUDA KEIICHI; OSHIMA TAKESHI
    权利人:SANKYO CO
    摘要:Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R 1 and R 2 are hydrogen or alkyl, one of A 1 and A 2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A 2 and hence are useful in the treatment of prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.

    专利号:US-2008242662-A1
    优先权日:2005-05-31
    标题 :Organic Compounds
    发明人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI
    权利人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI
    摘要:The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula I, n n n n n n n n n n wherein R1, R2, R11, C, E and D are as defined in the specification.

    专利号:US-10017481-B2
    优先权日:2012-03-17
    标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
    发明人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
    权利人:POLYPHOR AG
    摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

    专利号:US-6465507-B2
    优先权日:2000-02-28
    标题 :3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
    发明人:TANG PENG CHO; MILLER TODD A; LI XIAOYUAN; ZHANG RUOFEI; CUI JINRONG; HUANG PING; WEI CHUNG CHUN
    权利人:SUGEN INC
    摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

    专利号:CN-109369555-A
    优先权日:2018-11-29
    标题 :A kind of method of microwave radiation benzamide compound synthesis benzoxazoles in water phase
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    主要参考文献

    参考标题:A Novel Oxidative Procedure For The Synthesis Of Benzamides From Styrenes And Amines Under Metal-Free Conditions
    作者:Muhammad Sharif,Jin-Long Gong,Peter Langer,Matthias Beller,Xiao-Feng Wu
    摘要:An Interesting Procedure For The Oxidative Synthesis Of Amides From Styrenes And Amines Has Been Developed. Various Primary Amides Were Formed In Moderate Yields (25-81%). Secondary Amides Can Be Produced In Moderate Yields As Well (41-68%). Notably, No Transition Metal Catalyst Was Needed For This Transformation. This Is The First Example Of Oxidative Transformation Of Styrenes To Benzamides.

    合成参考文献


    摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 215.
    摘要:Eichman, C. C.; Stambuli, J. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 378.
    摘要:Jiao, N.; Li, Z., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 689.
    摘要:Pharmaceutical Chemistry Journal, 28(335), 1994
    参考文献:10.1007/bf01950008
    摘要:Piriou F, Petit JY, Welin L. Benzamide potentiation of behavioral apomorphine-induced effects; mechanism involved. Cellular and Molecular Life Sciences. 1985 Nov;41(11):1409–10. doi: 10.1007/bf01950008.
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