专利号:WO-2024108582-A1 优先权日:2022-11-25 标题:Recombinant strain, construction method therefor, and use thereof in preparation of quillaic acid 发明人:CHOU HOWARD H; YANG JIAZENG 权利人:SHENZHEN INST OF ADV TECH CAS 摘要:Provided are a recombinant strain, a construction method therefor, and a use thereof in the preparation of quillaic acid. In the recombinant strain, a coding sequence of an msbp protein is inserted, said msbp protein being able to promote cytochrome P450 oxidase in the recombinant bacteria to form a complex, and the yield of quillaic acid with cytochrome P450 oxidase participating in synthesis is increased.
专利号:WO-2024003514-A1 优先权日:2022-06-29 标题 :Methods and compositions relating to the synthesis of the qs-7 molecule 发明人:OSBOURN ANNE; REED JAMES; ORME ANASTASIA; MARTIN LAETITIA 权利人:PLANT BIOSCIENCE LTD 摘要:The present invention relates to a biosynthetic route to precursors of the QS-7 molecule, as well as routes to make the QS-7 molecule, enzymes involved, the products produced and uses of the product.
专利号:US-2025276992-A1 优先权日:2022-05-05 标题:Synthesis methods of acyl chain of qs-21 and derivative thereof 发明人:LAI MING-TAIN; LIN JHAO-LONG; LEE WEI-HAN; CHOU BING-CHENG 权利人:OBI PHARMA INC 摘要:The present disclosure provides synthesis methods used in the preparation of an acyl chain of QS-21 and its derivative.
专利号:US-11629162-B2 优先权日:2015-12-17 标 题:Triterpene saponin variants, methods of synthesis and use thereof 发明人:TAN DEREK S; GIN DAVID Y; WALKOWICZ WILLIAM E; FERNANDEZ-TEJADA ALBERTO; RAGUPATHI GOVINDASWAMI 权利人:MEMORIAL SLOAN KETTERING CANCER CENTER 摘要:A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
专利号:EP-3357931-B1 优先权日:2008-04-08 标 题:Methods of synthesis of triterpene prosapogenins and triterpene saponins
专利号:EP-3357931-A1 优先权日:2008-04-08 标 题 :Methods of synthesis of triterpene prosapogenins and triterpene saponins
1: Wang YC, Chen CR, Chen CY, Liang PH. Synthesis of Quillaic Acid through Sustainable C-H Bond Activations. J Org Chem. 2024 Apr 19;89(8):5491-5497. doi: 10.1021/acs.joc.3c02958. Epub 2024 Apr 10. 2: Yang J, Liu Y, Zhong D, Xu L, Gao H, Keasling JD, Luo X, Chou HH. Combinatorial optimization and spatial remodeling of CYPs to control product profile. Metab Eng. 2023 Nov;80:119-129. doi: 10.1016/j.ymben.2023.09.004. Epub 2023 Sep 12. 3: Li YH, Bai XS, Yang XX, Li YX, Li HR, Wang ZL, Wang W, Tian K, Huang XZ. Triterpenoid saponins from Psammosilene tunicoides and their antinociceptive activities. Phytochemistry. 2023 Oct;214:113795. doi: 10.1016/j.phytochem.2023.113795. Epub 2023 Jul 23. 13(3):226-235. doi: 10.1016/j.jtcme.2023.01.001.
合成参考文献
参考文献:10.1016/s1875-5364(09)60045-5 摘要:DENG X, LIU X, ZHU D, WANG Q. A New Triterpenoid Saponin from Psammosilene tunicoides. Chinese Journal of Natural Medicines. 2009 Mar;7(2):101–4. doi: 10.1016/s1875-5364(09)60045-5.