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N-(7H-嘌呤-6-基)辛酰胺置于n,O-双三甲硅基乙酰胺,三氟甲磺酸三甲基硅酯体系中,用 乙腈 作为反应溶剂,化学反应 2.25H,反应生成 3'-叠氮-2',3'-双脱氧腺苷
参考文献:大肠杆菌的核苷转运蛋白nupc和nupg:配体结合所必需的特定结构基序.
标题:大肠杆菌的核苷转运蛋白nupc和nupg:配体结合所必需的特定结构基序.
摘要:测试了一系列46种天然核苷和类似物(主要是基于腺苷的)作为从大肠杆菌中富集的,与h(+)连接的核苷转运蛋白nupc和nupg吸收[u-(14)c]尿苷的抑制剂.这两个在进化上不相关的转运蛋白显示出相似但不同的抑制模式,揭示了对不同核苷及其类似物的不同选择性.核苷与nupg的结合需要在核糖的c-3'和c-5'位置分别存在羟基,而与nupc的结合仅需要c-3'羟基取代基.核糖部分对于结合nupg的重要性更高,与该蛋白质和寡糖之间的进化关系一致:运输者的主要促进者超家族(mfs)的h(+)同向转运蛋白(ohs)亚家族.对于两种蛋白质,C-3'处的天然α-构型和c-1'处的天然β-构型对于配体结合都是必需的.发现腺苷的咪唑环中的n-7和c-6的氨基对于结合并不重要,并且两个转运蛋白都显示出c-6 / N取代的灵活性.n-1和n-3中的一个或两个对腺苷类似物与nupc的结合很重要,但对nupg的结合
DOI:10.1039/b414739A

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-5679785-A
优先权日:1990-12-11
标 题:3'(2')-amino- or thiol-modified, fluorescent dye-coupled nucleosides, nucleotides and oligonucleotides, and a process for the preparation thereof
发明人：ENGELS JOACHIM; HERRLEIN MATHIAS; KONRAD RENATE; MAG MATTHIAS
权利人:HOECHST AG
摘要:3'-(2')-Amino- or thiol-modified, fluorescent dye-coupled nucleosides, nucleotides and oligonucleotides, and a process for the preparation and the use thereof n The OH group located in the 3' and/or 2' position of a nucleoside, nucleotide or oligonucleotide is derivatized to an amino or thiol group and subsequently a fluorescent dye is coupled thereto. The resulting 3'- and/or 2'-amino- and thiol-modified nucleosides, nucleotides and oligonucleotides can then be used for the synthesis of complementary strands in the presence of a template strand or of oligonucleotides and for the detection of genetic material. They have the advantage that the fluorescent label need no longer be attached to the 5' end of the oligonucleotide or to the nucleobase, and thus need not be introduced during the chemical synthesis as in labeling techniques hitherto known, while the known and conventional methods have the disadvantage that only a few polymerases can be employed for the synthesis, the acceptance of the triphosphates by the polymerases diminishes and, moreover, a large substrate excess is necessary.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-2021332070-A1
优先权日:2018-04-04
标题:Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-11021497-B2
优先权日:2018-04-04
标题 :Compositions and methods for synthesis of phosphorylated molecules

专利号:US-2019154696-A1
优先权日:2015-08-31
标 题 :Colorimetric Labeling and Detection Methods and Compositions
发明人：CLARKE SCOTT; GEE KYLE; FINNESSY CARMEN
权利人:LIFE TECHNOLOGIES CORP
摘要:The present disclosure provides methods, compositions and kits for measuring cellular nascent nucleic acid synthesis by colorimetric labeling of nucleic acid. The nucleic acid synthesis can be measured as cell proliferation, DNA or RNA synthesis, gene expression or apoptosis. Additionally, these methods may be used to screen compounds for their effect on cellular proliferation by treating cells or an organism with the test compound simultaneous to or before treatment with a competitive nucleoside analog.