CAS: 700-35-6; 1-(2-Chloro-4-Fluorophenyl)Ethanone

该化合物是有机化合物,其特征为氯酮功能组和替代芳香环,该化合物在苯环上具有氯和氟替代成分,可影响其反应性和物理特性.一般而言,该化合物视温度和纯度而定,看上去无色可粉黄液体或固体,处理时应参考安全数据,因为卤素(氯和氟)的存在可加强其亲耳性,并可能影响其生物活动,使其对制药和农用化学研究感兴趣.该化合物的分子结构显示合成和作为生产更复杂的有机分子的中间体的潜在应用.此外,该化合物可能呈现出氯酮典型的特定再活动模式,如核剖分泌添加反应.在处理时,应参考安全数据,因为卤化化合物可构成健康和环境风险.

英文名称1-(2-Chloro-4-Fluorophenyl)Ethanone
中文名称2'-氯-4'-氟苯乙酮
IUPAC名称1-(2-chloro-4-fluorophenyl)ethan-1-one
其它别名1-(2-氯-4-氟苯基)乙酮; 2-Chloro-4-Fluoroacetophenone
CAS编号700-35-6
MFCD编号:MFCD00042202
EINECS号:615-053-0
分子式:C8H6ClFO
分子量:172.58
产品CID: 1694366
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: CSEMGLVHVZRXQF-UHFFFAOYSA-N
InChI=1S/C8H6ClFO/c1-5(11)7-3-2-6(10)4-8(7)9/h2-4H,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
皮肤腐蚀/刺激类别2
严重眼刺激类别2
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号2810
危险品标志Xi
风险等级Irritant
安全声明26-36/37/39
危险类别码22-36/38

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号625-98-9 间氯氟苯 | CAS号75-36-5 乙酰氯 | CAS号108-24-7 乙酸酐 | CAS号2252-51-9 2-氯-4-氟苯甲酸 | CAS号119851-28-4 2'-氯-4'-(4-氯苯氧基)苯乙酮

合成工艺路线路线简述

2-氯-4-氟苯甲酸置于1-羟基苯并三唑,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,三乙胺体系中,用四氢呋喃,二氯甲烷作为反应溶剂,化学反应 8.5H,反应生成 2-氯-4-氟苯乙酮
参考文献:Ep3333157
标题:Ep3333157

海关参考信息

2902600000-乙苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-8904827-A1
优先权日:1987-11-18
标题 :Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments

专利号:EP-0317149-B1
优先权日:1987-11-18
标题 :Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments

专利号:EP-0343206-A1
优先权日:1987-11-18
标题 :Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments

专利号:EP-0317149-A1
优先权日:1987-11-18
标题:Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments

专利号:US-8513241-B2
优先权日:2008-03-28
标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:CN-116444360-A
优先权日:2023-04-04
标题:Synthesis method of saflufenacil intermediate 2-chloro-4-fluorobenzoic acid