CAS: 72086-72-7; (S)-4-((Tert-Butoxycarbonyl)Amino)-5-Methoxy-5-Oxopentanoic Acid

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55227-00-4 5672-83-3 6384-08-3

上下游产品

CAS号59279-58-2 B°C-L-谷氨酸(苄酯)-1-甲酯 | CAS号13574-13-5 N-叔丁氧羰基-L-谷氨酸-5-苄酯 | CAS号59936-29-7 (S)-1-叔-丁基-2-甲基... | CAS号104706-58-3 B°C-Glu(OBzl)-OBt | CAS号56-86-0 L-谷氨酸 | CAS号1676-73-9 L-谷氨酸-γ-苄酯 | CAS号67-56-1 甲醇 | CAS号2419-94-5 B°C-L-谷氨酸 | CAS号1070-19-5 Carbonazidic ac... | CAS号5672-83-3 |N|-苄氧羰基-L-谷氨酸甲酯 | CAS号192314-71-9 (S)-2-[双(B°C)氨基... | CAS号188200-05-7 (S)-1-叔丁基 2-甲基 ... | CAS号4976-88-9 甲基(叔丁氧羰基)-L-谷氨酰胺

L-谷氨酸置于palladium On Activated Charcoal 硫酸,氢气,Potassium Carbonate,三乙胺体系中,用 乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 N-叔丁氧羰基-L-谷氨酸 1-甲酯
参考文献:设计和合成环状伪二肽的所有非对映异构体,以模拟环状cxcr4五肽拮抗剂.
标题:设计和合成环状伪二肽的所有非对映异构体,以模拟环状cxcr4五肽拮抗剂.
摘要:2,5-双[(3-胍基)丙基]-1-[3-(4-羟苯基)丙酰基]-7-(2-萘乙酰基)-1,4,7-三氮杂环十一烷基-9-En的四种非对映异构体-3-One(-)和2,5-双[(3-胍基)丙基]-1-(4-羟基苯基乙酰基)-7-(2-萘基乙酰基)-1,4,7-三氮杂环十一烷基-9-En通过发散的方法从i-和d-谷氨酸合成-3-一个(-).通过线性双(烯丙基胺)的闭环复分解反应制得11元环核,并使用双(boc)胍通过同时的两次mitsunobu反应引入胍基官能团.设计这些化合物以模拟环状五肽fc131(c [gly-D-Tyr-Arg-Arg-Nal]).
DOI:10.1039/b702649H

专利信息

专利号:US-2023151034-A1
优先权日:2020-03-17
标题:Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
发明人：JACOBSON IRINA C; LEE SAM SK; PIZARRO NOVOA JUAN CARLOS
权利人:COCRYSTAL PHARMA INC
摘要:Peptidomimetic N5-methyl-N2-(nonanoyl-L-leucyl)-L-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds for use in methods of inhibiting the replication of noroviruses and coronaviruses in a biological sample or patient, for use in reducing the amount of noroviruses or coronaviruses in a biological sample or patient, and for use in treating norovirus and coronavirus in a patient, comprising administering to said biological sample or patient a safe and effective amount of a compound represented by formulae I or II, or a pharmaceutically acceptable salt thereof. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. page 99 to page 271; examples 1 to 3; compounds A1 to A104 and B1 to B66; tables A to E).

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

专利号:US-2015150995-A1
优先权日:2012-08-09
标题:Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof
发明人：TAFT III KARL MILTON; ENGELKING JARRED ROY
权利人:PONO CORP
摘要:Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

专利号:CN-115611760-A
优先权日:2022-10-13
标 题 :Chemical synthesis method suitable for large-scale production of (S) -2-amino-5-alkynyl caproic acid