CAS: 130018-77-8; (R)-Cetirizine

上下游产品

西替利嗪 Cetirizine 83881-51-0
(R)-(2-{4-[(4-Chlorophenyl)Phenylmethyl]Piperazin-1-Yl}Ethoxy)Acetic Acid Methyl Ester
左氯替西汀酰胺杂质盐酸盐 (R)-2-(2-{4-[(4-Chlorophenyl)Phenylmethyl]Piperazin-1-Yl}Ethoxy)Acetamide 909779-33-5
(+)-[2-[4-[(4-氯苯基)-苯基甲基]-1-哌嗪基]]乙醇 (+)-[2-[4-[(4-Chlorophenyl)-Phenyl Methyl]-1-Piperazinyl]]Ethanol 705289-61-8
2-[4-[(4-氯苯基)苯基甲基]哌嗪-1-基]乙醇 2-{4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazin-1-Yl}Ethan-1-Ol 109806-71-5
R-2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-yl)-2-Oxoethoxy)Acetic Acid 1058165-14-2
左西替利嗪n-苄基酰胺 Levocetirizine N-Benzyl Amide 1150310-68-1
R-Methyl 2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-yl)-2-Oxoethoxy)Acetate 1201648-47-6 R-2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-yl)-2-Oxoethoxy)Acetyl Chloride (R)-1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine 300543-56-0

左氯替西汀酰胺杂质盐酸盐置于盐酸体系中,用 水 用作溶剂,化学反应 4.0H,反应生成左西替利嗪
参考文献:Process For Preparing (S) And (R)-2-[4-(4-Chlorobenzhydryl)Piperazin-1-Yl]-Ethoxyacetamide
标题:Process For Preparing (S) And (R)-2-[4-(4-Chlorobenzhydryl)Piperazin-1-Yl]-Ethoxyacetamide
摘要:本发明涉及一种通过使用多柱色谱分离外消旋混合物来制备(S)-2-[4-(4-氯苯基)-1-哌嗪基]-乙氧基乙酰胺和(R)-2-[4-(4-氯苯基)-1-哌嗪基]-乙氧基乙酰胺的方法.

专利信息

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:US-7619085-B2
优先权日:2005-03-03
标 题 :Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
发明人：PALACIO MAGALI; ATES CELAL
权利人:UCB PHARMA SA
摘要:The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylicacid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

专利号:US-7807837-B2
优先权日:2004-05-07
标 题 :Scalable synthesis of imidazole derivatives
发明人：JONES TODD K; MANI NEELAKANDHA
权利人:JANSSEN PHARMACEUTICA NV
摘要:Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.

专利号:EP-1354593-B1
优先权日:2002-04-08
标题 :use of an extract of a non-photosynthetic filamentous bacterium as an agent for enhancing the endogenous synthesis of superoxide dismutase
发明人：MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:Promoting endogenous production of superoxide dismutase (SOD) comprises the use of an extract (I) of non-photosynthetic, non-fruiting filamentous bacteria in cosmetic, dermatological or pharmaceutical applications. Use of an extract (I) of non-photosynthetic, non-fruiting filamentous bacteria: (1) in a composition based on a cosmetic medium, as an agent for promoting endogenous production of superoxide dismutase (SOD); or (2) for production of a pharmaceutical or dermatological composition for promoting endogenous production of SOD. Independent claim are also included for: (1) a composition comprising a physiological medium containing Vitreoscilla filliformis extract (Ia) and lycopene (specifically at 0.000000001-0.1 wt. %) or a compound having catalase activity and/or a compound having peroxidase activity; and (2) cosmetic treatment methods for treating loss of firmness and/or elasticity of the skin or for treating skin exposed to sunlight, involving application of compositions containing (Ia).

专利号:US-2006111369-A1
优先权日:2004-11-10
标 题:Synthesis, characterization and biological action of optically active isomers of floxacins
发明人：SOMBERG JOHN C; RANADE VASANT V
权利人:SOMBERG JOHN C; RANADE VASANT V
摘要:Disclosed herein is the method for synthesis and separation of enantiospecific isomers of floxacins. These isomers can be used to study the antibacterial action, as well as cardiac effects, such as arrhythmogenic activity, QT internal prolongation and dispersion, and Ikr inhibition in humans. A method for the identification of chiral isolates of the floxacins that are devoid or possess less QT prolonging action and thus cause less arthropathy especially of the Torsades de pointes variety. Also disclosed are methods for assaying these isomeric compounds present in the biological fluids.

专利号:US-7381821-B2
优先权日:2003-01-23
标 题 :Piperazine derivatives and their use as synthesis intermediates
发明人：ATES CELAL; CAVOY EMILE; BOUVY DIDIER
权利人:UCB SA
摘要:The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds