专利号:US-5286789-A 优先权日:1989-05-26 标题:Solid phase multiple peptide synthesis 发明人:OKRONGLY DAVID; CLARK BRIAN R; SPESARD JACK 权利人:APPLIED IMMUNESCIENCES 摘要:Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.
专利号:EP-0400920-B1 优先权日:1989-05-26 标 题 :Solid phase multiple peptide synthesis 发明人:OKRONGLY DAVID; CLARK BRIAN R; SPESARD JACK 权利人:APPLIED IMMUNESCIENCES 摘要:Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.
专利号:US-5663373-A 优先权日:1992-10-16 标题 :4-alkoxy-2, 6-di-t-butylphenol derivatives 发明人:TAMURA KUNIO; KATO YOSHIAKI; YOSHIDA MITSUTAKA; CYNSHI OSAMU; OHBA YASUHIRO 权利人:CHUGAI PHARMACEUTICAL CO LTD 摘要:Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: (I) where R1 is a hydrogen atom or an acyl group; R2 is a lower alkyl group; R3 is a hydrogen atom or a lower alkyl group; R4, R5 and R6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R2 and R4, when taken together, may form a 5-membered ring; R5 and R6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R6 is not present if the ring formed by R2 and R4 taken together is a benzofuran ring. The compounds represented by the general formula (I) have a highly selective anti-oxidative activity and are useful as therapeutics of ischemic diseases such as arteriosclerosis and myocardial infarction.
专利号:DE-69023546-T2 优先权日:1989-05-26 标题:Multiple solid phase synthesis of peptides.
专利号:RU-2417589-C9 优先权日:2004-07-30 标题:5-iodotetrazole derivatives, synthesis method thereof, fungicidal agent based on said derivatives, dispersion paint material containing said derivatives, method of protecting plants and dispersion paint materials from attack and/or decompositon by fungi
专利号:RU-2417589-C2 优先权日:2004-07-30 标 题 :5-iodotetrazole derivatives, synthesis method thereof, fungicidal agent based on said derivatives, dispersion paint material containing said derivatives, method of protecting plants and dispersion paint materials from attack and/or decompositon by fungi
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合成参考文献
摘要:Kanerva - Rustemeyer L, Elsner P, John SM, Maibach HI (eds). Kanerva's Occupational Dermatology, 2nd Ed. Berlin: Springer-Verlag, 2012., p. 406 摘要:Kanerva - Rustemeyer L, Elsner P, John SM, Maibach HI (eds). Kanerva's Occupational Dermatology, 2nd Ed. Berlin: Springer-Verlag, 2012., p. 407 参考文献:10.1007/s11030-005-8105-2 摘要:Lecarpentier P, Crosignani S, Linclau B. A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols. Mol Divers. 2005;9(4):341–51. doi: 10.1007/s11030-005-8105-2.