N-(4-碘苯基)乙酰胺置于盐酸,乙醇,水,氢溴酸,硝酸体系中,化学反应生成2-溴-4-碘苯胺 参考文献:Heisig,Journal Of The American Chemical Society,1928,Vol. 50,P. 143 标题:Heisig,Journal Of The American Chemical Society,1928,Vol. 50,P. 143
专利信息
专利号:US-12384788-B2 优先权日:2019-09-13 标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease 发明人:KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL 权利人:ORIGENIS GMBH 摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):
专利号:US-11149034-B2 优先权日:2017-07-25 标 题:Derivatives of luciferin and methods for their synthesis 发明人:JARDINE MOEGAMAT ANWAR; RYLANDS MARWAAN 权利人:UNIV CAPE TOWN 摘要:6-Thio derivatives of D-luciferin, also referred to as D-thioluciferins, having the general structure of Formula (I) are provided. Methods for synthesising D-luciferin, its derivatives, and their related 2-cyanobenzothiazole precursors are also provided. These compounds are commercially valuable due to their application in optical imaging, particularly in bioluminescence imaging.
专利号:WO-2019021202-A1 优先权日:2017-07-25 标题:LUCIFERIN DERIVATIVES AND METHODS OF SYNTHESIS
专利号:EP-3658544-B1 优先权日:2017-07-25 标 题 :Derivatives of luciferin and methods for their synthesis
专利号:EP-3658544-A1 优先权日:2017-07-25 标题:Derivatives of luciferin and methods for their synthesis
专利号:US-2020331902-A1 优先权日:2017-07-25 标题 :Derivatives of luciferin and methods for their synthesis
参考标题:Lewis Acid-Promoted Synthesis Of Unsymmetrical And Highly Functionalized Carbazoles And Dibenzofurans From Biaryl Triazenes: Application For The Total Synthesis Of Clausine C, Clausine R, And Clauraila A 作者:Weijun Yang,Jun Zhou,Binjie Wang,Hongjun Ren |发布日期:2011.12.2 摘要:A Natural Approach: A Lewis Acid‐promoted Nucleophilic Aromatic Substitution Approach To The Regioselective Synthesis Of Highly Substituted Carbazoles And Dibenzofurans Has Been Developed. The Annulation Process Is Applied To The Total Synthesis Of Carbazole Alkaloids Clausine C, Clausine R, And Clauraila A (See Scheme).