CAS: 33135-50-1; (3S,6S)-3,6-Dimethyl-1,4-Dioxane-2,5-Dione

专利信息

专利号:WO-2020253243-A1
优先权日:2019-06-20
标题:Process method for catalyzed synthesis of lactide with alkali metal compound
发明人：JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; CHEN JINLONG; ZHANG QUANXING
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD
摘要:The present invention provides a process method for catalyzed synthesis of lactide with an alkali metal compound, comprising: mixing an alkali metal compound with a lactic acid oligomer, and carrying out a cracking reaction to obtain lactide by means of vacuum distillation, wherein the alkali metal compound used is one or a plurality of an alkali metal carbonate, an alkali metal bicarbonate, and an alkali metal hydroxide. Compared with the prior art, the advantages of the present invention is that the alkali metal compound reacts and dissolves quickly after being added to the system avoiding the problem of pipeline blocking due to a catalyst not dissolving, the alkali metal compound used is cheap and readily available, the amount of the catalyst used is small, the yield of the reaction product lactide is greater than 80%, and the reaction is rapid and easy to industrialize.

专利号:WO-2020253244-A1
优先权日:2019-06-20
标 题 :Process for catalytic synthesis of lactide
发明人：JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; ZHANG QUANXING
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD
摘要:The present invention provides a process for the catalytic synthesis of lactide, comprising: mixing a lactic acid oligomer with a composite catalyst; and synthesizing lactide under a heating condition, and collecting the product using a vacuum distillation mode. The used composite catalyst is composed of a zinc or tin compound and an alkali metal compound. Compared with the prior art, the advantages of the present invention are that: the used composite catalyst features a high production rate with a small use amount, a low reaction temperature (150-220°C), and a short reaction time (2-5 h), has a single pass yield that may reach 95% or more, reduces energy consumption compared with the prior art, and facilitates industrial implementations.

专利号:US-11987567-B2
优先权日:2021-09-15
标题 :Synthesis method of lactide by confinement effect catalysis of crystalline porous polymer material
发明人：ZHAO YINGJIE; QIU WENQI; LIU HUI; ZHANG ZHENXIU; ZHAO JINYU
权利人:QINGDAO UNIV OF SCIENCE AND TECHNOLOGY
摘要:The present invention discloses a synthesis method of lactide by confinement effect catalysis of crystalline porous polymer material, wherein the method comprising: (I) synthesis of catalyst; (II) synthesis of lactide by confinement effect catalysis; and (III) purification of lactide. In the present invention, a yield of L-lactide by catalysis of L-lactic acid by crystalline polymers is as high as 85.6%, which is 10% higher than the yield of lactide by H-β molecular sieve reported in documents currently available; it is easy to prepare the crystalline porous polymer material catalyst, which is environmental friendly, has a high yield and is recyclable, for consecutive 7 times the catalysis yield is maintained to be higher than 70%, and catalysis yield conservation rate is far higher than catalysis effects of catalysts reported in documents currently available.

专利号:US-5981240-A
优先权日:1996-11-27
标题:Enzyme-catalyzed synthesis of macromolecules in organic solvents
发明人：AKKARA JOSEPH A; BRUNO FERDINANDO F
权利人:US ARMY
摘要:A method is described for a simple, fast and efficient synthesis of homopolymers and copolymers by the enzymatic ring opening polymerization of lactones and lactides. The enzyme used is an ion paired protease. The advantage of this enzymatic system is in using small amount of enzyme per monomer and lower reaction time. Homopolymers and copolymers are synthesized with molecular weights between 1000 and 4600 daltons, and dispersity as low as 1.1. The monomer conversion after 4 days, for reactions catalyzed by protease S, has reached 100%. Different initiators are used to control the rate and degree of polymerization. Synthesis of block copolymers with defined block size and crystallinity are described in this invention. These biodegradable and bioerodable polyesters and copolyesters with controlled molecular weight, dispersity and crystallinity have applications in medical, drug, cosmetic and food industries.

专利号:WO-2023152730-A1
优先权日:2022-02-14
标题 :Amine-borane adducts in the synthesis of polyester and its copolymers using cyclic esters and compositions thereof
发明人：FENG XIAOSHUANG; LIU JINGJING; GNANOU YVES
权利人:UNIV KING ABDULLAH SCI & TECH
摘要:Embodiments of the present disclosure provide for the process of synthesis of polyester and its copolymers through (co)polymerization of cyclic esters and with other oxygenated monomers using amine-borane adduct. Embodiments of the present disclosure further describe the controlled anionic ring-opening polymerization of the cyclic compounds. Embodiments of the present disclosure also describe the polymerization of cyclic compounds using the synergistic effect of amines and thioureas. Embodiments of the present disclosure also describe compositions of polymers formed by the said process.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.