CAS: 39755-95-8; 5-Methoxyindoline-2,3-Dione

上下游产品

CAS号6335-41-7 2-羟基亚胺-N-(4-甲氧基... | CAS号302-17-0 水合氯醛 | CAS号104-94-9 对甲氧基苯胺 | CAS号1006-94-6 5-甲氧基吲哚 | CAS号1189052-00-3 5-methoxy-2-nit... | CAS号79-37-8 草酰氯 | CAS号20265-97-8 对茴香胺盐酸盐 | CAS号20357-24-8 5-甲氧基-2-硝基苯甲醛 | CAS号52426-94-5 N,N'-bis(4-meth... | CAS号109103-45-9 3-(hydroxyamino... | CAS号52508-88-0 5-甲氧基-2-氧代吲哚啉-3-甲醛 | CAS号608-07-1 5-甲氧基色胺 | CAS号3416-18-0 5-羟基吲哚-2-酮 | CAS号90417-53-1 5-甲氧基-3-吲唑羧酸 | CAS号86-68-0 6-甲氧基喹啉-4-甲酸 | CAS号7699-18-5 5-甲氧基吲哚酮 | CAS号74588-78-6 d-64131 | CAS号16077-10-4 1-苯甲基-5-甲氧基二氢吲哚...

5-甲氧基吲哚-3-甲醛置于sodium Chloride体系中,用 水,乙腈 作为反应溶剂,化学反应 2.0H,以81%的收率获得产物5-甲氧基靛红
参考文献:氯化钠/ Oxone高效合成通用的合成子3-氯代吲哚
标题:氯化钠/ Oxone高效合成通用的合成子3-氯代吲哚
摘要:本工作描述了使用简单的可持续合成方法将吲哚-3-甲醛直接转化为3-氯氧吲哚的简便方法.从环境的角度出发,开发了一种在ch 3 Cn:H2O(1:1)系统中的nacl /恶烷组合物,用于多种吲哚衍生物的直接氧化氯化.这种氯化策略更可行,更便宜,并且易于获得潜在的3-氯代吲哚.另外,这种环境友好的方法也可适用于以高收率构建伊斯汀衍生物.
DOI:10.1039/c8Nj04855J

专利信息

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:US-2011263540-A1
优先权日:2008-07-25
标题 :Small-molecule inhibitors of protein synthesis inactivating toxins
发明人：PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.

专利号:US-2007299102-A1
优先权日:2004-04-08
标题:Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer
发明人：FELDING JAKOB; PEDERSEN HANS C; KROG-JENSEN CHRISTIAN; PRAESTEGAARD MORTEN; BUTCHER STEVEN P; LINDE VIGGO; COULTER THOMAS S; MONTALBETTI CHRISTIAN; UDDIN MOHAMMED; REIGNIER SERGE
权利人:TOPOTARGET AS
摘要:The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers is achieved in which inhibition of protein synthesis and/or inhibition of activation of the mTOR pathway is an effective method for reducing cell growth. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leukemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) n n nwherein at least one of X 1 and X 2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-2004067531-A1
优先权日:1997-08-20
标 题:Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
发明人：TANG PENG CHO; SUN LI; TRAN NGOC MY; NGUYEN ANH THI; NEMATALLA ASAAD
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:US-10456400-B2
优先权日:2014-05-17
标 题:Aza-ellipticine analogs, methods of synthesis and methods of treatment
发明人：LINDSEY CHRISTOPHER C; BEESON CRAIG C
权利人:MUSC FOUND FOR RES DEV
摘要:In some aspects, the present invention relates to aza-ellipticine compounds of the formula: wherein the variables are as defined herein. The application also provides novel methods of preparing aza-ellipticine compounds, methods of using the compounds, and pharmaceutical compositions thereof.