CAS: 403-19-0; 2-Fluoro-4-Nitrophenol

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CAS号100-02-7 对硝基苯酚 | CAS号402-67-5 间氟硝基苯 | CAS号367-12-4 2-氟苯酚 | CAS号7440-44-0 活性炭 | CAS号369-34-6 3,4-二氟硝基苯 | CAS号455-93-6 2-氟-4-硝基苯甲醚 | CAS号455-93-6 2-氟-4-硝基苯甲醚 | CAS号399-96-2 4-氨基-2-氟苯酚 | CAS号329-49-7 2-溴-6-氟-4-硝基苯酚 | CAS号394-50-3 3-氟水杨醛 | CAS号350-31-2 1-氯-2-氟-4-硝基苯 | CAS号437-83-2 3-氟-2-甲氧基苯胺 | CAS号320-76-3 4-溴-2-氟-6-硝基苯酚 | CAS号2045-39-8 Acetamide,N-(3-... | CAS号250371-88-1 4-(2-氟-4-硝基苯氧基)... | CAS号74266-66-3 4-溴-2-氟-6-硝基苯甲醚

对硝基苯酚置于n-Fluoropentachloropyridinium Triflate体系中,用 二氯甲烷 作为反应溶剂,化学反应 17.0H,以73%的收率获得产物2-氟-4-硝基苯酚
参考文献:功率和结构可变的氟化剂.n-氟吡啶鎓盐体系
标题:功率和结构可变的氟化剂.n-氟吡啶鎓盐体系
摘要:N-氟吡啶鎓盐提供了一种新的氟化剂系统,通过该系统,由于氟化能力的不同程度,反应性不同的各种亲核底物可以被氟化,并且还可以通过结构改变非常有选择性地氟化.在现有结果的基础上,选择性氟化的范围应该大大拓宽.因此,N-氟吡啶鎓盐系统应该可以制备许多有用的有机氟化合物
DOI:10.1021/ja00179A047

专利信息

专利号:US-2023248849-A1
优先权日:2020-07-27
标 题:Contrast agents for detection of enzyme activities based on melanin synthesis
发明人：PAGEL MARK D
权利人:UNIV TEXAS
摘要:We disclose a composition, comprising a compound, comprising a melanin precursor that spontaneously synthesizes a melanin when in free form in vivo, and a peptide directly covalently bonded to or indirectly linked to the melanin precursor, wherein the direct covalent bond or indirect link of the peptide to the melanin precursor blocks spontaneous synthesis of the melanin in vivo in the absence of protease activity. We also disclose methods of tumor imaging, tumor detection, diagnosis, and treatment, including methods comprising administering, to a patient suffering from a tumor, the composition; and either surgically resecting the tumor or thermally ablating the tumor, wherein the surgical resection is guided at least in part by contrast imparted by, or the thermally ablating targets cells containing, the melanin, wherein the melanin is spontaneously synthesized in the tumor after administering the composition.

专利号:US-2013004979-A1
优先权日:2010-06-11
标 题 :Glycosyltransferase reversibility for sugar nucleotide synthesis and microscale scanning
发明人：THORSON JON S; GANTT RICHARD W; PELTIER-PAIN PAULINE MARIE JEANNE
权利人:WISCONSIN ALUMNI RES FOUND; THORSON JON S; GANTT RICHARD W; PELTIER-PAIN PAULINE MARIE JEANNE
摘要:The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemo-enzymatic glycorandomization.

专利号:US-8372380-B2
优先权日:2007-03-30
标 题:In vivo imaging of sulfotransferases
发明人：BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
权利人:UNIV CALIFORNIA; BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
摘要:Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18 F, 123 I, 124 I, 125 I, or 11 C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.

专利号:US-5756834-A
优先权日:1995-11-11
标 题:Process for preparing fluorinated aromatics
发明人：PASENOK SERGEJ; APPEL WOLFGANG
权利人:HOECHST AG
摘要:It is known to prepare fluorinated aromatic compounds of the formula I in which X, Y and Z can have the meaning specified in the description, by reacting aromatic compounds of the formula II in which X, Y and Z have the meaning specified for formula I, with fluorine in a reaction medium. According to the invention, the direct fluorination is carried out in a reaction medium containing polyfluoroalkanesulfonic acids of the formula IIICFnH3-n(CFY)m-SO3H(III)in which m, n and Y have the meaning specified in the description. By this means, it is possible, particularly advantageously to provide a process, which improves the known processes not only with regard to the selectivity and the yield, but also with respect to the quality of the resulting products of the process in a manner not readily predictable. Fluorinated aromatic compounds of the formula I as intermediates for active compound synthesis.