CAS: 489-32-7; 5-Hydroxy-2-(4-Methoxyphenyl)-8-(3-Methylbut-2-En-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

上下游产品

CAS号38226-86-7 脱水淫羊藿素 | CAS号118525-40-9 去水淫羊藿黄素； 脱水淫羊藿素 | CAS号113558-15-9 宝藿苷I

山奈酚置于吡啶,盐酸,Tris(6,6,7,7,8,8-Heptafluoro-2,2-Dimethyl-3,5-octadionato)Europium(Iii),18-冠醚-6,1,4-环己二烯,Palladium 10% On Activated Carbon,氨,Potassium Carbonate,N,N-二异丙基乙胺,硫酸二甲酯,Silver Carbonate,Potassium Iodide,Silver(L) Oxide体系中,用 甲醇,二氯甲烷,氯仿,水,N,N-二甲基甲酰胺,氯苯,丙酮 作为反应溶剂,化学反应 118.83H,反应生成 淫羊藿苷
参考文献:通过区域选择性甲基化和对-Claisen-Cope重排从山ka酚中合成二十碳五烯.
标题:通过区域选择性甲基化和对-Claisen-Cope重排从山ka酚中合成二十碳五烯.
摘要:天然存在的生物活性类黄酮糖苷icariin(1)的半合成已通过11个步骤完成,山emp酚的总收率为7%.山emp酚的4'-Oh甲基化,3-O-甲氧基甲基-4'-O-甲基-5-O-异戊烯基-7-O-苄基山ka酚的8-烯丙基化(8) Nahco3存在下的eu(fod)3和icaritin(3)的糖基化是关键步骤.
DOI:10.3762/bjoc.11.135

专利信息

专利号:WO-2022116382-A1
优先权日:2020-12-04
标题 :Human glucagon-like peptide-1 receptor activator and application thereof
发明人：LI YINXIONG; XIONG YUE; FANG JI
权利人:GUANGZHOU INST BIOMED & HEALTH
摘要:A human glucagon-like peptide-1 receptor (GLP-1R) activator, comprising a compound of formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and R6 are each independently selected from any one of H, C1-C4 alkyl, mercapto, phosphate, vinyl, or acetyl. The compound of formula I or the pharmaceutically acceptable salt thereof can improve glycolipid metabolism of the tissue cells of a whole body, enhance the oxidative degradation of lipid molecules, inhibit the expression of lipogenic genes, inhibit the activity of acetyl coenzyme A synthetases, reduce the synthesis of triglyceride, improve the synthesis and secretion of glucose-induced insulin, relieve insulin antagonism, relieve the compensatory amplification of pancreatic islets β cells, and improve the survival rate and function of a pancreatic cell in a type-II diabetes sample state.

专利号:US-12342841-B2
优先权日:2020-09-28
标题:Compositions for improving low testosterone levels
发明人：AYYADURAI V A SHIVA; DEONIKAR PRABHAKAR
权利人:CYTOSOLVE INC
摘要:The present disclosure is related to dietary supplements. In some aspects, this disclosure relates to compositions that can include, one or more agents that can increase the synthesis of testosterone, decrease the degradation of testosterone, and/or decrease the oxidative stress. In some embodiments, an agent of the composition includes: a mineral, a carboxylic acid, a flavone, a flavan, a terpinoid, an amino acid, a benzopyran; and a glycoside, and a combination thereof.

专利号:US-2025236590-A1
优先权日:2021-10-20
标题 :A method for the preparation of indole-3-carboxylic acid derivatives
发明人：DEB INDUBHUSAN
权利人:DEB INDUBHUSAN
摘要:The present invention provides a new synthetic method for the preparation of building block indole-3-carboxylic acid (ICA) derivatives used as a key starting material to produce several artificial drugs. An efficient, safe, operationally simple, cost-effective method for the preparation of several ICA derivatives has been introduced in a very simple way. Utilizing easily available starting material, reagent, and solvent several key starting materials of ICA derivatives have been synthesized rapidly indicates the novel method is functional group tolerable. The preparation process does not involve use of any reducing agents or transition metals in the economically viable and operationally simple condition in one pot. ICA derivatives have been generated from isatin derivative in one step and this methodology is important with a wide range of applications from the drug development and material synthesis CN point of view.

专利号:CN-109674039-B
优先权日:2018-11-23
标题:Method and Application of Biotransformation Synthesis of Salidroside and Icariside D2

专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

专利号:CN-115353522-A
优先权日:2022-08-22
标 题:Regioselective Synthesis of Icaritin-Norcantharidin Conjugate and Its Antitumor Application