CAS: 607-97-6; Ethyl 2-Ethyl-3-Oxobutanoate

该化合物是一种多用途酯,通常用作有机合成的中间体,特别是在生产药品,农用化学品和精美化学品方面,其结构既包括Keto,也包括ester功能组,能够参与凝结,通电和Michael的补充反应.该化合物具有高度的回动性和选择性,对构建复杂的分子框架很有价值.在标准条件下和与各种溶剂的兼容性下,其稳定性增强了其在工业和实验室环境中的效用.

结构式图片

相似化合物

603-69-0 1522-34-5 609-14-3

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上下游产品

CAS号141-97-9 乙酰乙酸乙酯 | CAS号75-03-6 碘乙烷 | CAS号74-96-4 溴乙烷 | CAS号64-67-5 硫酸二乙酯 | CAS号10504-65-1 diphenylethylsu... | CAS号247098-17-5 ethyl 3-cyano-2... | CAS号1007476-32-5 sodium acetyl a... | CAS号66279-50-3 potassium salt ... | CAS号33283-91-9 Lithium-acetess... | CAS号15301-37-8 2-乙酰基-2-丁酸乙酯 | CAS号106515-42-8 1-(1,3-benzothi... | CAS号106515-43-9 1-(6-methoxy-1,... | CAS号106515-45-1 1-(6-fluoro-1,3... | CAS号106531-84-4 3,4-dimethyl-1-... | CAS号10606-53-8 5-乙基-6-甲基嘧啶-2,4-二醇 | CAS号53855-47-3 2-甲基吲哚-3-羧酸乙酯 | CAS号107-87-9 2-戊酮 | CAS号124-38-9 二氧化碳 | CAS号64-19-7 冰醋酸 | CAS号107-92-6 正丁酸

合成工艺路线路线简述

    3-Acetoxy-3-Cyano-2-Ethyl-3-Methyl-Propionic Acid Ethyl Ester置于sodium Tetrahydroborate体系中,用 甲醇 作为反应溶剂,化学反应生成 2-乙基乙酰乙酸乙酯
    参考文献:Bhandari,Kalpana; Sharma,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2004,Vol. 43,# 11,P. 2467-2470
    标题:Bhandari,Kalpana; Sharma,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2004,Vol. 43,# 11,P. 2467-2470

    海关参考信息

    专利信息


    专利号:CN-107876092-A
    优先权日:2017-11-24
    标 题 :High Stability Titanium Catalyst for the Synthesis of Benzyl Carbonate and Diphenyl Carbonate by Transesterification

    专利号:CN-104910104-B
    优先权日:2015-06-26
    标 题:A kind of method utilizing copper to catalyze the synthesis of dihydrofuran derivatives

    专利号:US-2009137557-A1
    优先权日:2005-11-22
    标题 :Calcilytic Compounds
    发明人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
    权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
    摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

    专利号:US-2005113397-A1
    优先权日:2002-01-31
    标题:Imidazo[1,2-a]pyridine derivative
    发明人:TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
    摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.

    专利号:CN-104803934-B
    优先权日:2015-05-04
    标 题:A kind of phenylisoxazole carboxylic acid compound with antitumor activity and its synthesis method and application

    专利号:US-8722887-B2
    优先权日:2006-09-22
    标 题:Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists
    发明人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
    权利人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G; ABBVIE BAHAMAS LTD
    摘要:This invention concerns compounds of the general formula (1): n nand derivatives thereof, which are antagonists of 5-HT 6 receptors, wherein the symbols have the meanings given in the description. The invention also concerns methods for the preparation of these compounds, to novel intermediates useful for their synthesis, and to uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in treating at least on disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes.
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    主要参考文献

    参考标题:Synthesis Of A Novel Library Of 1-Substituted Pyrido[1,2-A]Benzimidazoles
    作者:Satyanarayana Gadde,Yun Cheuk Leung,Mohan Bhadbade,Belamy B. Cheung,David Stc. Black,Naresh Kumar
    摘要:The Reactivity And Synthesis Of New Analogues Of Pyrido[1,2-A]Benzimidazoles Have Been Explored. Twenty-Three Derivatives Bearing Phenoxy, Thiophenoxy, Aniline, And Aryl Groups At The 1-Position Were Successfully Synthesised In 25-91 % Yield, Via Nucleophilic Substitution, Buchwald-Hartwig Amination, And Suzuki Coupling Type Processes. Solvent Free Synthetic Protocols Were Employed To Achieve The Nucleophilic

    合成参考文献


    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 29.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 168.
    摘要:Xia, F.; Ye, S., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 24.
    摘要:Vitale, M. R., Science of Synthesis, (2019) , 66.
    摘要:P. Rumpf and R. Reynaud, C. R. Acad. Sci., Ser. C 250, 1501 (1960).
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