专利号:CN-107876092-A 优先权日:2017-11-24 标 题 :High Stability Titanium Catalyst for the Synthesis of Benzyl Carbonate and Diphenyl Carbonate by Transesterification
专利号:CN-104910104-B 优先权日:2015-06-26 标 题:A kind of method utilizing copper to catalyze the synthesis of dihydrofuran derivatives
专利号:US-2009137557-A1 优先权日:2005-11-22 标题 :Calcilytic Compounds 发明人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S 权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S 摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
专利号:US-2005113397-A1 优先权日:2002-01-31 标题:Imidazo[1,2-a]pyridine derivative 发明人:TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI 摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
专利号:CN-104803934-B 优先权日:2015-05-04 标 题:A kind of phenylisoxazole carboxylic acid compound with antitumor activity and its synthesis method and application
专利号:US-8722887-B2 优先权日:2006-09-22 标 题:Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists 发明人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G 权利人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G; ABBVIE BAHAMAS LTD 摘要:This invention concerns compounds of the general formula (1): n nand derivatives thereof, which are antagonists of 5-HT 6 receptors, wherein the symbols have the meanings given in the description. The invention also concerns methods for the preparation of these compounds, to novel intermediates useful for their synthesis, and to uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in treating at least on disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes.
参考标题:Synthesis Of A Novel Library Of 1-Substituted Pyrido[1,2-A]Benzimidazoles 作者:Satyanarayana Gadde,Yun Cheuk Leung,Mohan Bhadbade,Belamy B. Cheung,David Stc. Black,Naresh Kumar 摘要:The Reactivity And Synthesis Of New Analogues Of Pyrido[1,2-A]Benzimidazoles Have Been Explored. Twenty-Three Derivatives Bearing Phenoxy, Thiophenoxy, Aniline, And Aryl Groups At The 1-Position Were Successfully Synthesised In 25-91 % Yield, Via Nucleophilic Substitution, Buchwald-Hartwig Amination, And Suzuki Coupling Type Processes. Solvent Free Synthetic Protocols Were Employed To Achieve The Nucleophilic
合成参考文献
摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 29. 摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 168. 摘要:Xia, F.; Ye, S., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 24. 摘要:Vitale, M. R., Science of Synthesis, (2019) , 66. 摘要:P. Rumpf and R. Reynaud, C. R. Acad. Sci., Ser. C 250, 1501 (1960).