CAS: 709031-39-0; (1S,3S,5S)-2-Azabicyclo[3.1.0]Hexane-3-Carboxamide Hydrochloride

相似化合物

361440-67-7 361440-68-8 1779416-42-0

L-焦谷氨酸乙酯置于盐酸,4-二甲氨基吡啶,Lithium Hydroxide Monohydrate,Diethylzinc,三乙基硼氢化锂,甲基磺酰氯,N,N-二异丙基乙胺体系中,用 四氢呋喃,乙二醇二甲醚,乙醇,二氯甲烷,水,乙酸乙酯,甲苯 作为反应溶剂,化学反应 32.25H,反应生成 (1S,3S,5S)-2-氮杂双环[3.1.0]己烷-3-甲酰胺盐酸盐
参考文献:Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor
标题:Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor
摘要:一种制备结构为的胺的方法,包括a. 用甲酸铵,烟酰胺腺嘌呤二核苷酸,二硫巯醇和部分纯化的苯丙氨酸脱氢酶和/或甲酸脱氢酶酶(pdh/fdh)处理结构为的酮酸的水溶液;和b. 用氢氧化钠调节反应混合物的ph值,形成所需的胺,该胺基本上不含有害的过量铵离子.

专利信息

专利号:US-9150511-B2
优先权日:2011-05-24
标题 :Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
发明人：KOVI RAVISHANKER; RAPOLE KESHAVRAO; NAIK ASHISH; KANNAPAN JAYARAMAN; MADALA MURALIKRISHNA; THAKOR SANJAY
权利人:APICORE US LLC
摘要:Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.