CAS: 102645-33-0; 2,5-Dichloroisonicotinaldehyde

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88912-26-9 623585-74-0 603122-76-5

上下游产品

CAS号16110-09-1 2,5-二氯吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1269771-37-0 2-(2,5-二氯吡啶-4-基...

2,5-二氯吡啶,N,N-二甲基甲酰胺置于正丁基锂,二异丙胺,盐酸,Sodium Hydroxide,水体系中,用 四氢呋喃,Hexanes 用作溶剂,化学反应 4.5H,反应生成2,5-二氯吡啶-4-醛
参考文献: P38 Kinase Inhibitors[fr] Inhibiteurs De La Kinase P38
标题: P38 Kinase Inhibitors[fr] Inhibiteurs De La Kinase P38
摘要:公式为(i)的化合物是p38激酶的抑制剂,可用于治疗由p38激酶活性介导或由p38活性产生的细胞因子介导的疾病或疾病状态.

专利信息

专利号:US-4504675-A
优先权日:1981-11-14
标 题 :Method for making isobutyric acid or esters thereof
发明人：BESECKE SIEGMUND; SIEGERT HERMANN-JOSEF; SCHROEDER GUENTER
权利人:ROEHM GMBH
摘要:What is disclosed is a process for the continuous production of isobutyric acid or an alkyl ester thereof by the Koch synthesis, which process comprises reacting propylene, carbon monoxide, and water or an alkanol in the presence of hydrogen fluoride in at least one reaction space containing a liquid phase and a gas phase under high pressure, releasing said pressure at least partially, whereby a gas containing organic compounds from said synthesis evolves from said liquid phase, adding oxygen to said evolved gas and at least partially combusting the organic compounds contained therein, then contacting the evolved gas containing the at least partially combusted organic compounds with at least a portion of the water or alkanol to be reacted with said propylene and carbon monoxide, whereby at least a portion of said combusted organic compounds are absorbed by said water or alkanol, returning said water or alkanol containing the absorbed combusted organic compounds to said reaction space, and discharging any unabsorbed gas from the reaction system.

专利号:US-4647696-A
优先权日:1979-12-20
标题 :Method for making isobutyric acid
发明人：BESECKE SIEGMUND; SCHROEDER GUENTER; SIEGERT HERMANN-JOSEF; GAENZLER WOLFGANG
权利人:ROEHM GMBH
摘要:What is disclosed is a continuous one-step method for the preparation of isobutyric acid or a lower alkyl ester thereof by the Koch synthesis, which method comprises reacting propylene, carbon monoxide, and water or a lower alcohol, in the gaseous and liquid phases, in the presence of hydrogen fluoride as a Koch catalyst, at a temperature between 80 DEG C. and 160 DEG C., at a dwell time of the liquid phase of less than 20 minutes, and with a high degree of backmixing, while maintaining the content of propylene in the reaction mixture at less than one percent by weight of the liquid phase, wherein all or part of the propylene, carbon monoxide, and water or lower alcohol can be replaced by binary addition compounds formed pairwise between these materials. In the alternative, isopropylformiate can be continuously rearranged in the presence of hydrogen fluoride to produce isobutyric acid.