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专利信息
专利号:EP-0406931-B1
优先权日:1989-06-30
标 题 :New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions
发明人:MARIOTTI SABINA; SISTO ALESSANDRO; NENCIONI LUCIANO; VILLA LUIGI; PESSI ANTONELLO
权利人:SCLAVO SPA
摘要:New thymopentin (TP5) analogues whose bonds in the peptide chain are all retro-inverted are disclosed. Such new compounds have the following general formula (I) wherein R is hydrogen or an acyl radical, and R<1> is a group of the formula -OR<2>, wherein R<2> is a hydrogen atom or a hydrocarbon radical, and the corresponding basic or acid addition salts which are pharmaceutically acceptable. The new compounds have immunostimulating activity.
专利号:US-5166394-A
优先权日:1990-05-23
标题 :Coupling reagent for peptide synthesis
发明人:BREIPOHL GERHARD; KOENIG WOLFGANG
权利人:HOECHST AG
摘要:Novel compounds of the formula I ##STR1## in which X is an anion, and a process for the preparation thereof, are described. Compounds of the formula I are used as coupling reagents in peptide synthesis.
专利号:US-5218089-A
优先权日:1988-12-23
标 题 :Retro-inverso analogues of thymopentin and the method for their synthesis
发明人:MARIOTTI SABINA; SISTO ALESSANDRO; NENCIONI LUCIANO; VILLA LUIGI; VERDINI ANTONIO S
权利人:SCLAVO SPA
摘要:New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP51-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described which are of the general formula (I) (I) where R is hydrogen or an acyl radical, and R1 is an -OR2 group or an group where R2 is a hydrogen atom or a hydrocarbon radical, and R3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
专利号:EP-0406931-A2
优先权日:1989-06-30
标题 :New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions
专利号:CA-2006561-A1
优先权日:1988-12-23
标题 :Retro-inverso analogues of thymopentin, the method for their synthesis and their use in the preparation of pharmaceutical compositions
专利号:RU-2109747-C1
优先权日:1992-04-04
标题 :Peptides, method of their synthesis, agent showing bradykinin-antagonistic activity