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乙酸-(4-甲氧基-5-甲基-2-硝基苯胺)置于sodium Hydroxide,硫酸体系中,化学反应生成5-硝基-2-甲基苯甲醚
参考文献:Orientation Studies In The Coumaran Series
标题:Orientation Studies In The Coumaran Series
摘要:
Doi:10.1021/ja01258A025

专利信息

专利号:WO-0073288-A1
优先权日:1999-05-28
标题 :Method for preparing 5-substituted oxazoles
发明人：WILSON JEFFREY; SNOONIAN JOHN
权利人:VERTEX PHARMA; WILSON JEFFREY; SNOONIAN JOHN
摘要:The invention provides a method for the preparation of 5-substituted oxazoles in high yield using inexpensive, widely available reagents. The method is particularly useful in the preparation of intermediates necessary in the synthesis of a class of IMPDH inhibitors, in particular VX-497, which is currently in clinical trials. The invention also provides compounds that represent novel intermediates useful in the methods of this invention.