CAS: 15260-10-3; (2S,3R)-3-(Benzyloxy)-2-((Tert-Butoxycarbonyl)Amino)Butanoic Acid

相似化合物

69355-99-3 117872-75-0 2592-18-9

上下游产品

CAS号4378-10-3 O-(苯基甲基)-L-苏氨酸 | CAS号98015-52-2 tert-butyl 1,2,... | CAS号185461-75-0 (2S,3R)-(2-(tri... | CAS号2592-18-9 B°C-L-苏氨酸 | CAS号100-39-0 溴化苄 | CAS号72-19-5 L-苏氨酸 | CAS号64263-80-5 N-叔丁氧羰基-N-甲基-O-... | CAS号103429-32-9 D-PHE-CYS-TYR-D... | CAS号103429-31-8 D-PHE-CYS-TYR-D... | CAS号254101-11-6 B°C-O-苄基-L-β-高苏氨酸 | CAS号2592-18-9 B°C-L-苏氨酸 | CAS号79069-63-9 n-b°C-(2s,3s)-2...

(2S,3R)-(2-(Trimethylsilyl)Ethoxy)Methyl 3-(Benzyloxy)-2-((Tert-Butoxycarbonyl)Amino)Butanoate置于magnesium Bromide体系中,用 二氯甲烷 用作溶剂,化学反应 3.0H,以83%的收率获得n-Boc-O-苄基-L-苏氨酸
参考文献:溴化镁对氨基酸和肽β-(三甲基甲硅烷基)乙氧基甲基(sem)酯的温和选择性裂解
标题:溴化镁对氨基酸和肽β-(三甲基甲硅烷基)乙氧基甲基(sem)酯的温和选择性裂解
摘要:先前已显示溴化镁醚化物可裂解脂肪族酸的β-(三甲基甲硅烷基)乙氧基甲基(sem)酯.在存在于肽化学中通常遇到的保护基的情况下,该方法现已扩展至氨基酸和肽衍生物,包括b°C,Cbz,Fmoc和troc氨基甲酸酯以及苄基,叔丁基和叔丁基二甲基甲硅烷基醚.氟化物敏感的保护基团对溴化镁的稳定性提高了有机合成中sem酯去除的选择性.
Doi:10.1016/s0040-4039(97)00863-0

专利信息

专利号:WO-2017178950-A1
优先权日:2016-04-11
标题 :Process for preparation of lanreotide acetate
发明人：GURJAR MUKUND KESHAV; TRIPATHY NARENDRA KUMAR; PRAMANIK CHINMOY MRIGANKA; DESHPANDE ASHISH PRAMOD
权利人:EMCURE PHARMACEUTICALS LTD
摘要:Disclosed herein is an improved 4+4 solution phase synthesis of Lanreotide acetate. The process comprises coupling of two suitably protected tetrapeptide fragments which on deprotection, oxidation, followed by treatment with acetic acid provides Lanreotide acetate having desired purify.

专利号:WO-2017212390-A1
优先权日:2016-06-06
标题:Process for lanreotide acetate preparation
发明人：GURJAR MUKUND; TRIPATHY NARENDRA; PRAMANIK CHINMOY; DESHMUKH SANJAY
权利人:EMCURE PHARMACEUTICALS LTD
摘要:The invention relates to an improved method for 4+4 solution phase synthesis of Lanreotide acetate (1) comprising coupling of two suitably protected tetrapeptide fragments which on deprotection, oxidation, followed by treatment with acetic acid to provide Lanreotide acetate (1) having desired purity.

专利号:WO-2019077507-A1
优先权日:2017-10-18
标 题:PROCESS FOR THE PREPARATION OF ACETATE OF LANREOTIDE
发明人：GURJAR MUKUND KESHAV; DESHMUKH SANJAY SHANKAR; HONPARKHE RAMCHANDRA BIRAPPA; HINGMIRE VAIBHAV SHIVAJI; KAPE SANDEEP ASHOK
权利人:EMCURE PHARMACEUTICALS LTD
摘要:The invention relates to an improved lanreotide acetate solution phase synthesis method (1), comprising coupling two appropriately protected tetrapeptide fragments, the threonine hydroxyl being protected, to give an octapeptide, which after deprotection, oxidation, followed by treatment with acetic acid, provides lanreotide acetate (1) of desired purity.