CAS: 1679-07-8; Cyclopentanethiol

该化合物是一种循环硫醇化合物,其特点是五人组成的碳环,具有硫化氢(-SH)功能组,有机硫化合物因其强大,独特的气味和活性而引人注目,在有机合成和工业应用中具有价值,其循环结构具有稳定性,而硫醇组则能够参与硫醇-乙烯反应,金属协调以及核生殖替代.Cycloptenethiol 通常用作制药,农用化学品和特殊化学品的建筑块,还作为催化中的悬浮剂和改变聚合物特性的前体,妥善处理因其挥发性和潜在刺激性而必不可少.

结构式图片

相似化合物

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欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    Cyclopentyl(Naphthalen-1-yl)Sulfane置于aluminosilicate体系中,化学反应生成环戊硫醇
    参考文献:Tits-Skvortsova,I.N. Et Al.,Journal Of General Chemistry Of The Ussr,1960,Vol. 30,P. 1000-1006
    标题:Tits-Skvortsova,I.N. Et Al.,Journal Of General Chemistry Of The Ussr,1960,Vol. 30,P. 1000-1006

    专利信息


    专利号:US-8293930-B1
    优先权日:2004-06-25
    标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
    发明人:NAIDU RAGINA
    权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
    摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

    专利号:US-7893283-B2
    优先权日:2004-06-04
    标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
    发明人:NAIDU RAGINA
    权利人:CHATHAM BIOTEC LTD
    摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

    专利号:US-8476441-B2
    优先权日:2009-01-29
    标 题 :Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
    发明人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN
    权利人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN; TRINITY COLLEGE DUBLIN
    摘要:(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.

    专利号:WO-2008032104-A1
    优先权日:2006-09-15
    标题:One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
    发明人:WALKER ROSS THOMSON; NAIDU RAGINA
    权利人:CHATHAM BIOTEC LTD; WALKER ROSS THOMSON; NAIDU RAGINA
    摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction, of protecting the C-10 and attaching a side chain at C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and intermediates used therein.

    专利号:US-7202370-B2
    优先权日:2003-10-27
    标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
    发明人:NAIDU RAGINA
    权利人:CONOR MEDSYSTEMS INC
    摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.

    专利号:US-2013338369-A1
    优先权日:2011-03-07
    标 题 :Process for the Synthesis of Aminobiphenylene
    发明人:HEINRICH MARKUS; PRATSCH GERALD
    权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
    摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
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    合成参考文献


    摘要:Beier, P., Science of Synthesis Knowledge Updates, (2014) 2, 315.
    摘要:Kashemirov, B. A.; Błażewska, K.; Justyna, K.; Lyu, J.; McKenna, C. E., Science of Synthesis Knowledge Updates, (2021) 1, 412.
    摘要:Fan, Y. C.; Kwon, O., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 770.
    摘要:Ronson, T. O.; Fairlamb, I. J. S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 187.
    摘要:Patil, N. T.; Tathe, A. G.; Bhoyare, V. W., Science of Synthesis, (2019) , 127.
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