专利号:WO-2021260722-A1 优先权日:2020-06-21 标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase 发明人:GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA 权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT 摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.
专利号:US-10188136-B2 优先权日:2016-02-16 标题:Hydrophobin mimics: process for preparation thereof 发明人:BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan; BHANDARI PAVANKUMAR JANARDHAN; RAO KASULADEVU JAGANNADHA 权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES 摘要:The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.
专利号:US-6187923-B1 优先权日:1998-11-09 标题 :Process for the synthesis of quinazolinones 发明人:DENER JEFFREY MARK; LY CUONG QUOC 权利人:AXYS ADVANCED TECHNOLOGIES INC 摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:
专利号:US-8273403-B2 优先权日:2002-05-10 标题 :Generation of surface coating diversity 发明人:BARDEN MICHAEL C; KAMBOURIS PETER A 权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD 摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.
专利号:US-4288453-A 优先权日:1977-10-07 标 题 :Derivatives of arylalkanoic acids, compositions and use 发明人:VINCENT MICHEL; DUHAULT JACQUES; BOULLANGER MICHELLE; REMOND GEORGES 权利人:SCIENCE UNION & CIE 摘要:There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD 50 greater than 800 mg/kg, intraperitoneally, in male mice. n A method of use, compositions, and a process for synthesis are also described.
专利号:US-10458995-B2 优先权日:2016-03-25 标 题 :Combinatorial synthesis and biomarker development 发明人:MOOLA MURALIDHAR REDDY 权利人:MOOLA MURALIDHAR REDDY 摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.
参考标题:Facile Synthesis Of Controllable Graphene-Co-Shelled Reusable Ni/nio Nanoparticles And Their Application In The Synthesis Of Amines Under Mild Conditions 作者:Jianguo Liu,Yuting Zhu,Chenguang Wang,Thishana Singh,Nan Wang,Qiying Liu,Zhibing Cui,Longlong Ma 摘要:Catalysts Are Stable And Reusable And Were Successfully Used For The Synthesis Of Primary, Secondary, Tertiary, And N-Methylamines (More Than 62 Examples). The Reaction Couples Easily Accessible Carbonyl Compounds (Aldehydes And Ketones) With Ammonia, Amines, And H2 Under Very Mild Industrially Viable And Scalable Conditions (80 °C And 1 Mpa H2 Pressure, 4 H), Offering Cost-Effective Access To Numerous Functionalized
合成参考文献
参考文献:10.1126/sciadv.abf8711 摘要:Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT; QCRG Structural Biology Consortium, Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv. 2021 Apr;7(16).