CAS: 34183-22-7; 1-(2-(2-Hydroxy-3-(Propylamino)Propoxy)Phenyl)-3-Phenylpropan-1-One Hydrochloride

2'-Hydroxydihydrochalcone Sodium 反应 15.0H,反应生成 盐酸普罗帕酮
参考文献:一种盐酸普罗帕酮及其中间体2'-羟基二氢查尔酮的制备方法
标题:一种盐酸普罗帕酮及其中间体2'-羟基二氢查尔酮的制备方法
摘要:本发明公开了一种盐酸普罗帕酮及其中间体2'‑羟基二氢查尔酮的制备方法,本发明采用2‑苯基‑苯并噻唑啉为还原剂构建还原体系,对碳碳双键进行还原,可高效的选择性还原底物中双键,避免了盐酸普罗帕酮关键中间体2'‑羟基二氢查尔酮使用氢气合成的问题.所用还原剂简单易得,对反应设备及操作要求低,适于工业化生产,无需氢气和贵金属,安全环保.

专利信息

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9745419-B2
优先权日:2014-01-24
标 题 :Aqueous polyglycidol synthesis with ultra-low branching
发明人：HARTH EVA M; SPEARS BENJAMIN R
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-2024097977-A1
优先权日:2022-11-04
标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery
发明人：SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S
权利人:TUFTS COLLEGE
摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.

专利号:US-2016206743-A1
优先权日:2012-06-15
标题 :Linear Polyester and Semi-Linear Glycidol Polymer Systems: Formulation and Synthesis of Novel Monomers and Macromolecular Structures

专利号:US-2014005278-A1
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures

专利号:US-9161983-B2
优先权日:2012-06-15
标题:Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures