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专利信息

专利号:WO-2025120678-A1
优先权日:2023-12-08
标 题 :A process for synthesis of poly-γ-glutamic acid
发明人：DHARNE MAHESH SHANTAPPA; YADAV RAKESHKUMAR JAYNARAYAN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a field of biopolymers and microbial fermentation. Specifically, the present invention relates to a microbial process for industrial production of a biopolymer. More particularly, the present invention relates to a process for synthesis of poly-γ-glutamic acid from maltose and sugarcane bagasse. The process of the present invention is devoid of pre- treating of raw materials (biomass) thereby eliminating environmental and cost concerns.

专利号:WO-2023102770-A1
优先权日:2021-12-08
标 题:High-added-value metabolite chassis created based on artificial intelligence
发明人：LUO XIAOZHOU; DENG HUAXIANG; Deng Yanwu; YU HAN; QIU YULAN
权利人:SHENZHEN INST OF ADV TECH CAS; SENRIS BIOTECHNOLOGY SHENZHEN CO LTD
摘要:A high-added-value metabolite chassis created based on artificial intelligence, relating to the technical fields of synthetic biology and metabolic engineering. By using artificial intelligence technology, by means of few-shot sampling, 'design-build-test-learn' closed-loop, cyclic learning of promoter and target metabolite yield data are achieved, a promoter library of high-added-value core metabolic flow key genes is continuously acclimatized, target core metabolic pathway resource allocation is optimized, and a high-yield and high-added-value metabolite chassis is obtained. Also provided are a creation method and a use of said high-added-value metabolite chassis created based on artificial intelligence. The problem that a high-added-value metabolite has no high-throughput molecular probe or molecular probe screening is unstable can be effectively solved, the labor cost is reduced, the microbial metabolic regulation time is shortened, an inhibitory effect between an intermediate product and a final product is eliminated, the core metabolic flux is enhanced, and efficient synthesis of high-added-value compounds is achieved.

专利号:WO-2025181459-A1
优先权日:2024-02-26
标题:Engineering bacterial cells for hydrogen production
发明人：TU WEIMING; THOMPSON IAN; HUANG WEI
权利人:UNIV OXFORD INNOVATION LTD
摘要:The invention relates to an electromicrobial system for synthesis of hydrogen, comprising: a gram-negative bacterial cell modified for synthesis of hydrogen, wherein the bacterial cell comprises: i) inner membrane-bound rhodopsin for proton-pumping, ii) membrane-bound hydrogenase, and iii) optionally an electron mediator located in the periplasm and/or on the outer membrane of the bacterial cell; and an electron source for donation of electrons to the bacterial cell.

专利号:WO-2023246071-A1
优先权日:2022-06-22
标题 :Mrec mutant and use thereof in l-valine fermentative production
发明人：ZHANG XUELI; GUO HENGHUA; LIU PINGPING; ZHANG DONGZU; TANG JINLEI; LIU SHUPENG
权利人:ANHUI HUAHENG BIOTECHNOLOGY CO LTD; TIANJIN INST IND BIOTECHNOLOGY CAS; HEFEI HUAHENG BIOENGINEERING CO LTD; BAYANNUR HUAHENG BIOTECHNOLOGY CO LTD
摘要:The present invention provides an mreC mutant and use thereof in L-valine fermentative production. The mreC mutant is a protein obtained by mutating proline at position 150 in the wild-type mreC amino acid sequence into leucine. The introduction of an mreC point mutation into the microbial genome, i.e., a C-to-T mutation at position 449 of the coding region in the wild-type mreC gene nucleotide sequence, can significantly improve the production capacity and biomass of an engineering strain of a high valine production. The knock-out and introduction of related enzyme genes of the L-valine anaerobic fermentation pathway further provide proper carbon metabolic flows and reducing capacity balance control in the L-valine production process. By the coordinative regulation of multiple genes, a metabolic pathway suitable for L-valine fermentative production is formed, thus achieving a high-level synthesis of L-valine in microorganisms.

专利号:WO-2023067251-A1
优先权日:2021-10-22
标 题:Composition for use in the cutaneous synthesis of hyaluronic acid, in an immuno-cutaneous response and to improve skin

专利号:WO-2024082334-A1
优先权日:2022-10-20
标题 :Melt electrowriting-based carbon fiber-silk fibroin composite material for microbial culture and preparation method therefor
发明人：MA MINGLEI; LI TIANMING; Jia Zhengmiao; LI ZHONGYUAN; ZHANG SHIWU; LI SHIYANG; TANG LIANG; SUN YUE; Meng Daijun
权利人:UNIV SHANGHAI; CHINA CONSTR 8TH ENG DIVISION
摘要:Provided are a melt electrowriting-based carbon fiber-silk fibroin composite material for microbial culture and a preparation method therefor, relating to the field of microbial culture. Silk fibroin, diatomite powder, and high polymer powder serve as electrowriting raw materials for physical blending and then serve as melt electrowriting raw materials, and the blend is spray-extruded onto carbon fibers infiltrated in a hyaluronic acid solution, so as to prepare the melt electrowriting-based carbon fiber-silk fibroin composite material. A large specific surface area is provided on a carbon fiber substrate to obtain a larger attachment site. The silk fibroin and a high polymer have good biocompatibility, and are biodegradable, providing nutrient substances for microorganisms, promoting the synthesis of bacteria and good biological affinity for microorganism growth. In addition, diatomite can provide mineral substances for the growth of the microorganisms, facilitating the growth and reproduction of the microorganisms. The carbon fibers are infiltrated in the hyaluronic acid solution, and then covered by electrowriting with silk fibroin or similar substances, thus realizing the slow-release effect of hyaluronic acid and prolonging the service cycle of a microbial carrier.