CAS: 6306-60-1; 2-(2,4-Dichlorophenyl)Acetonitrile

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CAS号773837-37-9 sodium cyanide | CAS号94-99-5 2,4-二氯氯苄 | CAS号19719-28-9 2,4-二氯苯乙酸 | CAS号877468-98-9 2,4-dichloro-1-... | CAS号10442-39-4 氰化四丁基胺 | CAS号1058649-24-3 2,4-dichloro-1-... | CAS号151-50-8 氰化钾 | CAS号143-33-9 氰化钠 | CAS号1777-82-8 2,4-二氯苄醇 | CAS号95-73-8 2,4-二氯甲苯 | CAS号209412-09-9 2-(6-CHLORO-3-P... | CAS号2184-86-3 (2R)-2-(2,4-二氯苯基)戊腈 | CAS号874-42-0 2,4-二氯苯甲醛 | CAS号53056-20-5 2,4-二氯苯乙酰氯 | CAS号52516-13-9 2,4-二氯苯乙胺 | CAS号103754-45-6 2-(2,4-二氯苯基)琥珀酸 | CAS号310466-16-1 2-(2,4-二氯苯基)-乙脒 | CAS号333748-88-2 (E)-2-(2,4-二氯苯基... | CAS号148477-71-8 螺螨酯 | CAS号19719-28-9 2,4-二氯苯乙酸

2,4-二氯苄醇置于二乙胺基三氟化硫,三(五氟苯基)硼烷,N,N-二异丙基乙胺体系中,用 二氯甲烷,1,2-二氯乙烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 19.08H,反应生成 2,4-二氯苯乙腈
参考文献:通过伪卤化物中间体对脂肪族氟化物进行亲核取代
标题:通过伪卤化物中间体对脂肪族氟化物进行亲核取代
摘要:已经报道了用多种亲核试剂将脂肪族氟化物官能化的方法.通过使用甲硅烷基化的假卤化物tms-Oms或tms-Ntf 2热力学驱动碳-氟键裂解,导致形成tms-F和捕获的脂族假卤化物中间体.氟化物/假卤化物的交换速率和该中间体的稳定性使得在直链脂肪族氟化物中几乎看不到末端氟化物的重排.将有机氟化物位置转化为假卤化物基团的能力允许各种亲核试剂容易地进行亲核攻击.亲核试剂的后期引入还允许偶联伴侣具有广泛的功能基团耐受性.在存在其他烷基卤化物的情况下观测到选择性的烷基氟化物甲磺酰化,从而允许正交合成策略.
DOI:10.1002/chem.201806272

专利信息

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.

专利号:CN-115819215-A
优先权日:2022-11-08
标题:A kind of method for the synthesis of carboxylic acid derivatives by Lewis acid catalysis

专利号:US-6245773-B1
优先权日:1996-05-16
标题:5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
发明人：WONG WAI C; LAGU BHARAT; NAGARATHNAM DHANAPALAN; MARZABADI MOHAMMAD R; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to dihydropyrimidine compounds of the following formula: n which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:US-4460604-A
优先权日:1976-06-03
标 题 :4-Amino-4-aryl-cyclohexanones
发明人：LEDNICER DANIEL
权利人:UPJOHN CO
摘要:A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.

专利号:US-6620815-B1
优先权日:1997-06-18
标题:Oxazolidinones and uses thereof
发明人：LAGU BHARAT; DHAR T G MURALI; NAGARATHNAM DHANAPALAN; JEON YOON T; MARZABADI MOHAMMAD R; WONG WAI C; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to oxazolidinone compounds which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:CN-117603029-A
优先权日:2023-11-21
标题:Synthesis method of penconazole key intermediate