CAS: 694-52-0; 4-Fluoropyridine

上下游产品

4-aminopyridine hydrogen fluoride water pyridine 1-(4'-pyridyl)-4-pyridone 5,8-endoxo-5,8-dihydroisoquinoline 3-methyl-N-(4-pyridyl)indole 4-fluoro-3-methylsilylpyridine

Potassium Pyridine-4-Trifluoroborate置于potassium Fluoride,Copper(II) Bis(Trifluoromethanesulfonate)体系中,用 乙腈 作为反应溶剂,化学反应 20.0H,反应生成 4-氟吡啶
参考文献:Cu(Otf)2-介导的芳基三氟硼酸盐与氟化钾的氟化
标题:Cu(Otf)2-介导的芳基三氟硼酸盐与氟化钾的氟化
摘要:本通讯描述了 Cu(Otf)2 介导的芳基三氟硼酸盐与 Kf 的氟化.该反应在温和条件下进行(60°C,20 小时),显示出广泛的底物范围和官能团耐受性.cu 被提议在这种转化中扮演两个独立的角色:(1)作为芳基-F 偶联的介体和(2)作为氧化剂用于获得提议的 Cu(iii)(芳基)(f)中间体.
DOI:10.1021/ja408607R

专利信息

专利号:US-10011567-B1
优先权日:2017-03-09
标题 :Method for the synthesis of acrylate derivatives
发明人：WANG MINGWEN; ZHANG YUE
权利人:INNOSCI LLC
摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.

专利号:WO-2025122636-A1
优先权日:2023-12-04
标题:Method for the synthesis of acrylate derivatives
发明人：CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN
权利人:ORTHOBOND CORP
摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.

专利号:WO-2023213264-A1
优先权日:2022-05-05
标 题 :Synthesis of amide compound and use thereof
发明人：WANG ZHAOYIN; ZHANG JIAN; CAO JINRUI
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:The present invention relates to a novel oleanamide derivative for activating a KEAP/NRF2/ARE signaling pathway. The compound of the present invention is represented by general formula (I), wherein L, R 3 , R 4 , Z, and n are set forth in the description specification and the claims. Also disclosed are a method for preparing the compound represented by general formula I and an activity test result thereof for activating the KEAP/NRF2/ARE signaling pathway. The compound represented by general formula (I) of the present invention can be used for treating and preventing multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), spinal muscular atrophy (SMA), neuromyelitis optica (NMO), spinocerebellar ataxia (SCA), and other neurodegenerative diseases, and can also be used for treating cerebral apoplexy, autoimmune diseases, diabetes, kidney diseases, and other chronic diseases.

专利号:US-2017355648-A1
优先权日:2016-04-26
标题 :Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

专利号:US-8697888-B2
优先权日:2012-01-06
标题 :Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; CHEUNG YIU-YIN
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: