2-溴丙酸置于氯化亚砜体系中,化学反应生成 2-溴丙酰氯 参考文献:Catalytic Asymmetric Cyclization Of Some Bromohydrins With Chiral Cobalt Complex 标题:Catalytic Asymmetric Cyclization Of Some Bromohydrins With Chiral Cobalt Complex 摘要:在存在光学活性的钴(Salen)型复杂物的情况下,研究了多种溴醇与碱的非对称环化反应.获得了光学纯度适中的光学活性环氧烷.赤霉-3-溴-2-丁醇和反霉-3-溴-2-丁醇进行了类似的环化,分别仅获得了反-2,3-二甲基环氧烷和顺-2,3-二甲基环氧烷,这表明溴醇的环化过程通过完全的sn2型反应进行. DOI:10.1246/bcsj.61.603
专利号:US-5693720-A 优先权日:1994-03-22 标 题:Solid-phase synthesis utilizing photochemical carbon-sulfur bond cleavage of thioethers 发明人:SUCHOLEIKI IRVING 权利人:LILLY CO ELI 摘要:A method for photochemical cleavage of carbon-sulfur bonds in conjunction with solid-phase synthesis utilizing a deoxygenated solvent and light to cleave the carbon-sulfur bond from a heterogeneous support. Also disclosed are compounds for use with said photochemical cleavage and methods of preparing them.
专利号:US-5231179-A 优先权日:1986-01-27 标题 :Heterocyclic compounds and their production 发明人:TERASHIMA SHIRO; ITO YOSHIO; KAWABATA TAKEO; SAKAI KUNIKAZU; HIYAMA TAMEJIRO; KIMURA YOSHIKAZU; SUNAGAWA MAKOTO; TAMOTO KATSUMI; SASAKI AKIRA 权利人:SUMITOMO PHARMA 摘要:A compound of the formula: (I) wherein R1, R2, R3 and R4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R1 and R2 may be combined together to form a lower alkylene group and/or R3 and R4 are combined together to form a lower alkylene group, or R1, R2, R3 and R4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1 beta -methylcarbapenem compounds valuable as antibiotics.
专利号:US-9351974-B2 优先权日:2011-11-10 标题 :Substituted pteridinones for the treatment of cancer 发明人:JIN MEIZHONG; KADALBAJOO MRIDULA; LI AN-HU; MULVIHILL MARK J; SIU KAM W; STEINIG ARNO G; WANG JING 权利人:OSI PHARMACEUTICALS LLC 摘要:Compounds of Formula I, as shown below and defined herein: n npharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven or mediated at least in part by RSK. This Abstract is not limiting of the invention.
专利号:CN-113173894-B 优先权日:2021-06-04 标 题:A kind of method for continuous synthesis of tetrahydrofuran-3-one
专利号:EP-0946526-B1 优先权日:1996-12-04 标 题 :Macrocyclic metal complex carboxylic acids, use and method for the production thereof 发明人:PLATZEK JOHANNES; SCHMITT-WILLICH HERIBERT; RADUECHEL BERND 权利人:SCHERING AG 摘要:The invention relates to novel macrocyclic metal complex carboxylic acids of formula (II), wherein Z DEG means a metal iron equivalent of atomic numbers 58-71 and R is a CHX<1>-CO-NH-CHY<1>-(CH2)f-COOH group, wherein X<1> and Y<1> mean individually a hydrogen atom, a straight-chained or branched C1-C7-alkyl radical, a phenyl or benzyl group and f means the figures 0-9. Said acids can be used as intermediate preparations for synthesis of cascade polymer complexes suitable as diagnostic agents.
专利号:US-5919433-A 优先权日:1996-12-04 标 题:Macrocyclic metal complex carboxylic acids, their use as well as process for their production 发明人:PLATZEK JOHANNES; RADUECHEL BERND; SCHMITT-WILLICH HERIBERT 权利人:SCHERING AG 摘要:The invention relates to new macrocyclic metal complex carboxylic acids of formula II whereby Zo stands for a metal ion equivalent of atomic numbers 58-71 and R stands for a CHX1-CO-NH-CHY1-(CH2)f-COOH group, in which X1 and Y1, independently of one another, mean a hydrogen atom, a straight-chain or branched C1-C7 alkyl radical, a phenyl or benzyl group and f means numbers 0 to 9. They can be used as intermediate stages for synthesis of cascade polymer complexes that are suitable as diagnostic agents.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 406. 摘要:Riva, R.; Banfi, L.; Basso, A., Science of Synthesis: Multicomponent Reactions, (2013) 1, 407.