CAS: 7425-63-0; Methyl Bromopyruvate

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1113-59-3 70-23-5 629659-95-6

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CAS号67-56-1 甲醇 | CAS号1113-59-3 3-溴丙酮酸 | CAS号600-22-6 丙酮酸甲酯 | CAS号27871-49-4 L-乳酸甲酯 | CAS号62235-61-4 3-(溴甲基)喹喔啉-2(1H)-酮 | CAS号1000576-38-4 2-氨基-4-噁唑羧酸甲酯 | CAS号118452-04-3 2-氨基噻唑-4-甲酸甲酯 | CAS号16754-74-8 methyl 2-oxo-3-... | CAS号1206972-73-7 IMidazo[1,2-a]p... | CAS号1206981-34-1 8-氯咪唑并[1,2-a]吡嗪... | CAS号7113-02-2 2-苯基噻唑-4-羧酸甲酯 | CAS号87597-22-6 咪唑并[1,2-A]吡嗪-2-羧酸甲酯 | CAS号6436-60-8 2-甲基噻唑-4-甲酸甲酯

丙酮酸甲酯置于溴,溶剂黄146体系中,化学反应生成 溴代丙酮酸甲酯
参考文献: Efficient And Scalable Systhesis Of 2-(1'H-Indole-3'-Carbonyl)-Thiazole-4-Carboxylic Acid Methyl Ester And Its Structural Analogs[fr] Procédés De Synthèse Efficaces Et Adaptables De L'Ester De Méthyle D'Acide 2-(1'H-Indole-3'-Carbonyl)-Thiazole-4-Carboxylique Et De Ses Analogues Structuraux
标题: Efficient And Scalable Systhesis Of 2-(1'H-Indole-3'-Carbonyl)-Thiazole-4-Carboxylic Acid Methyl Ester And Its Structural Analogs[fr] Procédés De Synthèse Efficaces Et Adaptables De L'Ester De Méthyle D'Acide 2-(1'H-Indole-3'-Carbonyl)-Thiazole-4-Carboxylique Et De Ses Analogues Structuraux
摘要:合成2-(1'H-吲哚-3'-甲酰基)-噻唑-4-羧酸甲酯(ite)及其结构类似物的方法.这些方法包括缩合反应或缩合和氧化反应,以形成ite或其结构类似物的噻唑啉或噻唑基团.

专利信息

专利号:US-4316029-A
优先权日:1979-06-22
标 题:Synthesis of vincaminic acid derivatives
发明人：ROSSEY GUY
权利人:SYNTHELABO
摘要:Vincaminic acid derivatives of formula (A) ##STR1## useful in treating cerebral insufficiency, are prepared by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine with the 2,4-DNP hydrazone of ethyl or methyl bromopyruvate followed by (i) reduction of the Câ•?N bond and (ii) simultaneous cyclization with removal of the ketone-protecting group in either order.

专利号:US-10081610-B2
优先权日:2014-09-12
标题 :Efficient and scalable synthesis of 2-(1′h-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs
发明人：SONG JIASHENG; ZHANG SUOMING; LI GUODONG; YANG LUQUING
权利人:ARIAGEN INC
摘要:Methods of synthesizing 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ITE or its structural analogs.

专利号:US-11465997-B2
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents
发明人：NICOLAOU KYRIACOS C; BELLAVANCE GABRIEL; BUCHMAN MAREK; PULUKURI KIRAN KUMAR; RIGOL STEPHAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

专利号:US-2017291881-A1
优先权日:2014-09-12
标 题:Efficient and scalable synthesis of 2-(1'h-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs

专利号:EP-3641891-A1
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents

专利号:US-2021155616-A1
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents