CAS: 1128-23-0; (3S,4R,5R)-5-((S)-1,2-Dihydroxyethyl)-3,4-Dihydroxydihydrofuran-2(3H)-One

相似化合物

6322-07-2 1198-69-2 22430-23-5

上下游产品

CAS号50-81-7 抗坏血酸 | CAS号367523-78-2 2,3,4,6-trimeth... | CAS号389-36-6 糖质酸-1,4-内酯 | CAS号87-73-0 葡萄糖二酸 | CAS号50-81-7 抗坏血酸 | CAS号609-06-3 L-木糖 | CAS号73285-50-4 (2R,3R,4R,5S)-2... | CAS号112837-17-9 5-(甲氧基)2-(5H)-二氧三环酮 | CAS号118464-49-6 5-叠氮基-6-(叔丁基二甲基... | CAS号36326-38-2 (E)-3-(2,2-二甲基-... | CAS号62362-63-4 D-甘露聚糖-γ-内酰胺 | CAS号815-53-2 2,3-dioxopropan... | CAS号75-07-0 乙醛

甘露醇置于rh(H)(Pet3)3 苄叉丙酮体系中,用 N,N-二甲基甲酰胺 用作溶剂,以90%的收率获得l-甘露糖酸-1,4-内酯
参考文献:A New Efficient Access To Glycono-1,4-Lactones By Oxidation Of Unprotected Itols By Catalytic Hydrogen Transfer With Rhh(Pph3)4-Benzalacetone System
标题:A New Efficient Access To Glycono-1,4-Lactones By Oxidation Of Unprotected Itols By Catalytic Hydrogen Transfer With Rhh(Pph3)4-Benzalacetone System
摘要:使用rhh(Pph3)4-苯甲醛乙酮体系处理未保护的戊糖醇和己糖醇,可专一性地以60-96%的收率生成糖醛-1,4-内酯.
Doi:10.1055/s-1998-1705

专利信息

专利号:US-4861892-A
优先权日:1988-02-12
标题:Method for synthesis of deoxymannojirimycin
发明人：FLEET GEORGE W J
权利人:SEARLE & CO
摘要:A method is disclosed for the chemical synthesis of 1,5-dideoxy-1,5-imino-D-mannitol or 1,5-dideoxy-1,5-imino-L-mannitol from, respectively, 2,3-O-isopropylidene-L-gulono-γ-lactone or 2,3-O-isopropylidene-D-gulono-γ-lactone which comprises carrying out interconversion between the L-gulono and D-mannono forms or between the D-gulono and L-mannono forms, respectively, and connecting of C-1 to C-5 by nitrogen.

专利号:US-2017348280-A1
优先权日:2016-06-06
标题 :Counteracting the inhibition of collagen synthesis by select calcium and sodium channel blockers using ascorbic acid and ascorbyl palmitate
发明人：RATH MATTHIAS W; NIEDZWIECKI ALEKSANDRA; IVANOV VADIM O; IVANOVA SVETLANA V
权利人:RATH MATTHIAS W; NIEDZWIECKI ALEKSANDRA; IVANOV VADIM O; IVANOVA SVETLANA V
摘要:A therapeutic use of ascorbyl palmitate, ascorbic acid and/or derivatives thereof to reverse or counter the adverse effects of channel blockers in the medical management of cardiovascular disease in a subject is presented. Effects of select Na- and Ca-channel blockers on collagen synthesis and deposition were evaluated in cultured human dermal fibroblasts and aortic smooth muscle cells by immunoassay. Ca and Na-channel blockers inhibited the synthesis of collagen type I and collagen type IV, the basic molecules of vascular wall stability. The inhibitory effects of the calcium and sodium channel blockers on collagen synthesis was reversed by introducing ascorbic acid and/or ascorbyl palmitate. It can be concluded that calcium and sodium channel blockers have a direct inhibitory effect on collagen synthesis, favoring the instability of the vascular wall and the progression of cardiovascular disease, an effect that is mitigated by treatment with, ascorbyl palmitate, ascorbic acid and or derivatives thereof.

专利号:WO-9614060-A1
优先权日:1994-11-04
标题 :Use of receptor agonists to stimulate superoxide dismutase activity
发明人：MARKLUND STEFAN L; STRAALIN PONTUS
权利人:MARKLUND STEFAN L; STRAALIN PONTUS
摘要:The present invention relates to the use of a substance for the manufacture of a composition for stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells. In particular, the invention relates to the use of a substance for the manufacture of a composition for prophylaxis or treatment of a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical. Further, the invention relates to a method for determining the effect of a substance with respect to stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells and to substances which have been selected by said method. Within the scope of the invention is a method of preventing, diminishing, controlling or inhibiting a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical in a patient who has been established to have a high risk of developing a such disease or disorder, or who has developed a such disease or disorder, the method comprising administering an effective amount of a substance which is capable of stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells.

专利号:US-7652172-B2
优先权日:2004-09-20
标题:Expeditious synthesis of DPD
发明人：SEMMELHACK MARTIN F; CAMPAGNA SHAWN R; BASSLER BONNIE L; FEDERLE MICHAEL J
权利人:UNIV PRINCETON
摘要:This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.

专利号:US-8383346-B2
优先权日:2008-06-13
标 题 :Combined automated parallel synthesis of polynucleotide variants
发明人：COLBECK JEFFREY; MIJTS BENJAMIN; GIVER LORRAINE JOAN; FOX RICHARD J; MITCHELL VESNA; PAK BUMSHIK ROBERT; GILSON LYNNE
权利人:CODEXIS INC; COLBECK JEFFREY; MIJTS BENJAMIN; GIVER LORRAINE JOAN; FOX RICHARD J; MITCHELL VESNA; PAK BUMSHIK ROBERT; GILSON LYNNE
摘要:The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.

专利号:US-4259443-A
优先权日:1979-02-05
标 题 :Synthesis of ascorbic acid from lactose
发明人：DANEHY JAMES P
权利人:BERNARD WOLNAK AND ASSOCIATES
摘要:A method of synthesizing vitamin C (ascorbic acid) directly from the hydrolysis products of lactose. Lactose, economically obtained from whey, undergoes hydrolysis with a warm aqueous slurry of lactase to produce D-galactose and D-glucose. Preparing the methyl glycosides of these two sugars protects a labile C-O linkage during the oxidation of the sugars to D-galacturonic acid and D-glucuronic acid. The mixture of these acids, after the removal of the methyl group through hydrolysis, undergoes reduction with gaseous hydrogen in the presence of an Adams catalyst or Raney nickel to produce a mixture of L-gulonic acid and L-galactonic acid. Removing the water from these acids forces their conversion into the corresponding lactones. Because of the applicable rate constants, adding water to the lactones does not result in their rapid reconversion to the acids. Accordingly, they can then undergo oxidation, in the presence of an enzyme obtained from pea seeds, to L-ascorbic acid.