CAS: 128430-66-0; 2-(Chloromethyl)-3-Methyl-4-(2,2,2-Trifluoroethoxy)Pyridine

相似化合物

127337-60-4 127337-60-4 256642-27-0

上下游产品

CAS号103577-66-8 [3-甲基-4-(2,2,2-... | CAS号103577-61-3 2, 3-二甲基-4-(2,2... | CAS号112525-75-4 2-Acetoxymethyl... | CAS号103577-40-8 兰索拉唑硫醚 | CAS号103577-45-3 兰索拉唑

6-(Chloromethyl)-5-Methyl-4-(2,2,2-Trifluoroethoxy)-2,3,4,5-Tetrahydropyridine置于双氧水,C22H18Mnn2O5体系中,用 乙醇 用作溶剂,化学反应 5.0H,以84.6%的收率获得2-氯甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶
参考文献:一种兰索拉唑关键中间体的制备方法
标题:一种兰索拉唑关键中间体的制备方法
摘要:本发明涉及一种兰索拉唑关键中间体的制备方法.本发明的技术方案是:首先分别制备(2,2,2‑三氟乙氧基)乙烯(化合物7)和3‑氨基‑4‑氯‑2‑甲基丁‑2‑烯酸乙酯(化合物9);然后二者反应制备6‑(氯甲基)‑5‑甲基‑4‑(2,2,2‑三氟乙氧基)‑2,3,4,5‑四氢吡啶;最后是6‑(氯甲基)‑5‑甲基‑4‑(2,2,2‑三氟乙氧基)‑2,3,4,5‑四氢吡啶(化合物10)在四苯基卟啉氧锰(mn(O)‑salon)的催化作用下被过氧化氢氧化生成2‑(氯甲基)‑3‑甲基‑4‑(2,2,2‑三氟乙氧基)吡啶(化合物5).本发明技术方案减少了危险性,降低能耗,更适合大规模工业化生产.

专利信息

专利号:US-8962851-B2
优先权日:2011-12-27
标题:One-pot process for the preparation of benzimidazole derivatives
发明人：DWIVEDI SHRIPRAKASH DHAR; PRASAD ASHOK; PAL DAYA RAM
权利人:CADILA HEALTHCARE LTD
摘要:The present invention discloses one pot process for enantioselective synthesis of single enantiomers of substituted sulphoxides 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles or said compounds in an enantiomerically enriched form.

专利号:US-8829014-B2
优先权日:2006-04-07
标题 :Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
发明人：GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S
权利人:GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S; UNIV LOUISIANA STATE; PATEL PHARMACEUTICAL EDUCATION & RES DEV PERD CT B V
摘要:Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

专利号:CN-110873767-A
优先权日:2018-09-04
标 题:A kind of rapid detection method of dexlansoprazole synthesis intermediate and related substances

专利号:CN-113773301-A
优先权日:2021-10-11
标 题:A kind of lansoprazole synthesis method