乙醇置于三氯氧磷体系中,用75%的收率获得二氯磷酸乙酯 参考文献:合成von Phosphorsäure烷基酯二酰胺 标题:合成von Phosphorsäure烷基酯二酰胺 摘要:在 Vorangegangenen 手套.Beschrieben Wir Verfahren Zur Darstellung Von Phosphorsäure-Phenylester-Und Phosphorsäure-4-Nitro-Phenylester-N,N'-Diamiden.In Der Vorliegenden Veröffentlichung Wird Die Synthese Von Phosphorsäurealkylester-N,N'-Diamiden Aus Phosphorsäurealkylesterdichloride Und Primären Aminen Geschildert. Doi:10.1002/ardp.19823150703
专利号:US-10111867-B2 优先权日:2015-02-17 标题:Process and intermediates for the preparation of perampanel 发明人:MAROM EHUD; RUBNOV SHAI 权利人:MAPI PHARMA LTD 摘要:The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.
专利号:WO-2007057690-A1 优先权日:2005-11-18 标题:Desymmetrisation process for the production of cyclic phosphines used as ligands in enantioselective synthesis catalysts 发明人:GOUVERNEUR VERONIQUE 权利人:ISIS INNOVATION; GOUVERNEUR VERONIQUE 摘要:The present invention relates to a process for producing P-chiral cyclic phosphines, to a process for producing P-prochiral phosphine derivatives, to a process for preparing the (E,E) geometric isomers of P-chiral phosphine derivatives, to the P-prochiral phosphine derivatives, to the P-chiral cyclic phosphine derivatives, to hydroxyalkylphenylphosphine derivatives, to catalysts comprising the P-chiral cyclic phosphine derivatives or the hydroxyalkylphenylphosphine derivatives, to catalysts comprising a metal and a ligand where the ligand is, is derivable from or is obtainable from the P-chiral cyclic phosphine derivatives or the hydroxyalkylphenylphosphine derivatives, to the use as a catalyst of the P-chiral cyclic phosphine derivatives or the hydroxyalkylphenylphosphine derivatives, to the use as a catalyst of a compound comprising a metal and a ligand where the ligand is, is derivable from or is obtainable from the P-chiral cyclic phosphine derivatives or the hydroxyalkylphenylphosphine derivatives, and to a process for synthesising an organic compound whereby the synthesis includes and enantioselective reaction catalysed by the above catalyst.
专利号:CA-2743700-C 优先权日:2008-12-15 标题 :Stereoselective synthesis of piperidine derivatives
专利号:JP-2012512172-A 优先权日:2008-12-15 标 题:Stereoselective synthesis of piperidine derivatives.
专利号:RU-2021277-C1 优先权日:1991-01-14 标 题:Method of synthesis of o-methyl- or o-ethyldichlorophosphates
专利号:US-7022842-B2 优先权日:2000-12-21 标 题:Process for synthesizing beta-lactam 发明人:HATAKEDA KIYOTAKA; SATO OSAMU; KANAKUBO MITSUHIRO; IKUSHIMA YUTAKA; TORII KAZUO 权利人:NAT INST OF ADVANCED IND SCIEN 摘要:It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the present invention relates to a β-lactam synthesis method which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that β-lactams are synthesized at a high speed by cyclizing β-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200° C. or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing β-lactams which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.
参考文献:10.1007/s00216-014-7826-4 摘要:Wensbo Posaric D, Andersson A, Bergquist K, Isaksson A. Differentiation and quantification of synthetic phosphatidylethanol (PEth) homologues by 1H- and 13C-NMR in polar organic solvents. Analytical and Bioanalytical Chemistry. 2014 May 28;406(19):4735–44. doi: 10.1007/s00216-014-7826-4.