CAS: 17136-36-6; 2-(Benzylamino)Acetic Acid

相似化合物

7689-50-1 107-97-1 1138-80-3

上下游产品

CAS号6436-90-4 N-苄基甘氨酸乙酯 | CAS号7662-76-2 2-(苄基氨基)乙酸叔丁酯 | CAS号1634-04-4 甲基叔丁基醚 | CAS号17360-47-3 2-(二苄基)乙酸 | CAS号100-52-7 苯甲醛 | CAS号56-40-6 甘氨酸 | CAS号100-46-9 苄胺 | CAS号875656-66-9 N-benzylidene g... | CAS号598-21-0 溴乙酰溴 | CAS号772312-20-6 Acetic acid, [(... | CAS号5747-92-2 1-苄基吡咯烷-3-甲酸乙酯 | CAS号17136-35-5 2-(苄基氨基)乙酸甲酯 | CAS号201405-92-7 2-[benzoyl(benz... | CAS号76315-01-0 N-B°C-N-苄基甘氨酸 | CAS号132414-78-9 1-苄基六氢吡咯并[3,4-b... | CAS号141743-13-7 2-((((9H-芴-9-基)... | CAS号13657-16-4 3-苄基恶唑烷 | CAS号35404-63-8 Glycine, N-(ami... | CAS号17012-21-4 N-苄基-3-吡咯烷甲酸甲酯 | CAS号165893-99-2 2,5-二苄基四氢吡咯并[3,...

(二苄基氨基)乙酸置于盐酸,钯体系中,化学反应生成N-苄基甘氨酸
参考文献:Velluz Et Al.,Bulletin De La Societe Chimique De France,1954,P. 1015
标题:Velluz Et Al.,Bulletin De La Societe Chimique De France,1954,P. 1015

专利信息

专利号:US-5977301-A
优先权日:1992-09-24
标题 :Synthesis of N-substituted oligomers
发明人：ZUCKERMAN RONALD N; KERR JANICE M; KENT STEPHEN B H; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:EP-0671928-B1
优先权日:1992-09-24
标题 :Synthesis of n-substituted oligomers
发明人：ZUCKERMANN RONALD N; KERR JANICE M; KENT STEPHEN BRIAN HENRY; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:Poly N-substituted Glycines (poly NSGs), wherein the substituents bear purine or pyrimidine bases (R<9>) every second glycine: In addition, a solid phase method for the synthesis of N-substituted oligomers of more general structures is disclosed.The poly NSGs obtainable by this method can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using the automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:WO-9001493-A1
优先权日:1988-07-29
标 题:Method for controlling solid-phase synthesis of biopolymers
发明人：BARU MIKHAIL BORISOVICH; RODIONOV IGOR LEONIDOVICH; SHESTAKOVSKY LEONID YAKOVLEVIC; LARIN VYACHESLAV TARASOVICH
权利人:SP K BJURO BIOLOG
摘要:A method for controlling the solid-phase synthesis of biopolymers carried out on a non-solid polymer carrier provides for determining the initial volume of the carrier and subsequently measuring the volume of the carrier together with the substance generated at each phase of the synthesis. The total volume gradient of the carrier together with the substance generated is determined when the gradient reaches zero the next phase of the synthesis is started.

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:EP-0535155-B1
优先权日:1990-06-14
标 题:Libraries of modified peptides with protease resistance
发明人：BARTLETT PAUL A; SANTI DANIEL; SIMON REYNA
权利人:CHIRON CORP; UNIV CALIFORNIA
摘要:Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.

专利号:WO-2011091548-A1
优先权日:2010-01-27
标 题:Method for cucurbitine synthesis
发明人：CHANG XIAOWEI; KHOSHDEL EZAT; PENG WEIMIN; WANG JINFANG; YAO YINFANG
权利人:UNILEVER PLC; UNILEVER NV; UNILEVER HINDUSTAN; CHANG XIAOWEI; KHOSHDEL EZAT; PENG WEIMIN; WANG JINFANG; YAO YINFANG
摘要:A method for the synthesis of cucurbitine comprising the step of forming a pyrrolidine ring by a 1,3 dipolar cycloaddition reaction.