CAS: 2050-08-0; Amyl Salicylate

该化合物是来自硅酸盐酸和五硝酸酯的酯,该化合物的特征是清晰,无色至黄色的浅色外观和温柔芳香味,主要用作个人护理和化妆品中的紫外线吸收剂和香味成分,因为它能够吸收紫外线辐射在紫外线-B射程中.它的亲脂性增强了与油基系统的兼容性,使之适合日光检查,润滑剂和其他专题应用.该化合物的稳定性和低挥发性有助于其长效的配方.此外,该化合物还表现出温和的抗微生物特性,进一步扩大了其在防腐系统中的用途.

结构式图片

欧盟法规

欧盟化妆品法规附录三-限用物质清单REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

pentan-1-ol salicylic acid salicylaldehyden-amyl O-(3-dimethylaminopropyl)salicylate n-amyl O-(3-diethylaminopropyl)salicylate n-amyl O-(2-diisopropylaminoethyl)salicylate n-amyl O-(3-dimethylamino-2-methylpropyl)salicylate

合成工艺路线路线简述

    N-Amyl 2-Oxo-3-Cyclohexenoate置于1% Pd/c,Potassium Nitrite体系中,化学反应生成水杨酸戊酯
    参考文献:Cn116693392
    标题:Cn116693392

    海关参考信息

    专利信息


    专利号:US-7598291-B2
    优先权日:2004-09-02
    标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
    发明人:NIMNI MARCEL; HAN BO
    权利人:NIMNI MARCEL; HAN BO
    摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

    专利号:US-2010160244-A1
    优先权日:2004-09-02
    标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
    发明人:NIMNI MARCEL; HAN BO
    权利人:NIMNI MARCEL; HAN BO
    摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

    专利号:US-9051302-B2
    优先权日:2008-01-15
    标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
    发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
    权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
    摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

    专利号:US-12194020-B2
    优先权日:2017-12-22
    标 题:Reversing baldness through cannabinoid receptor activation
    发明人:POSTREL RICHARD
    权利人:POSTREL RICHARD
    摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

    专利号:US-7329767-B2
    优先权日:2003-10-03
    标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
    发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

    专利号:US-8007841-B2
    优先权日:2003-10-03
    标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
    发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
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    主要参考文献


    1: Bernardini I, Fabrello J, Vecchiato M, Ferraresso S, Babbucci M, Peruzza L, Rovere GD, Masiero L, Marin MG, Bargelloni L, Gambaro A, Patarnello T, Matozzo V, Milan M. Effects of environmental concentrations of the fragrance amyl salicylate on the mediterranean mussel Mytilus galloprovincialis. Environ Pollut. 2022 Aug 15;307:119502. doi: 10.1016/j.envpol.2022.119502. Epub 2022 May 20.
    165:105247. doi: 10.1016/j.marenvres.2020.105247. Epub 2021 Jan 2.
    157:276-283. doi: 10.1016/j.plaphy.2020.10.026. Epub 2020 Oct 29. 566-567:1362-1367. doi: 10.1016/j.scitotenv.2016.05.198. Epub 2016 Jun 4. 593-594:375-379. doi: 10.1016/j.scitotenv.2017.03.197. Epub 2017 Mar 27. 21(6):599-603. doi: 10.1248/bpb.21.599.

    合成参考文献


    参考文献:10.18632/aging.100021
    摘要:Choi SH, Bosetti F. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY). 2009 Feb 11;1(2):234–44.
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