CAS: 2106-18-5; 2-(Trifluoromethoxy)Fluorobenzene

上下游产品

fluorobenzene bis(trifluoromethyl)peroxide 2-fluoro-1-iodo-3-(trifluoromethoxy)benzene benzhydrylidene-(2-fluoro-3-trifluoromethoxy-phenyl)-amine 2-fluoro-3-(trifluoromethoxy)aniline hydr°Chloride 1-fluoro-4-amino-2-trifluoromethoxybenzene

2-氟苯胺,Trifluoromethyl 4-Fluorobenzenesulfonate置于tetrafluoroboric Acid,亚硝酸特丁酯,Tris(2,2-Bipyridine)Ruthenium(II) Hexafluorophosphate,三氟甲烷磺酸亚铜(I)苯联合体 (2:1),Cesium Fluoride体系中,用 乙醇,水,乙腈 用作溶剂,化学反应 13.0H,以27%的收率获得2-氟三氟甲氧基苯
参考文献:四氟硼酸arenediazonzonium的可见光光氧化还原催化和铜促进的三氟甲氧基化
标题:四氟硼酸arenediazonzonium的可见光光氧化还原催化和铜促进的三氟甲氧基化
摘要:我们报道了用三氟甲基芳基磺酸盐(tfms)作为三氟甲氧基化试剂的光氧化还原催化和铜促进的芳构氮杂四氟硼酸盐的三氟甲氧基化.这种新方法利用了可见光的光氧化还原催化作用,在温和的条件下生成了芳基,并结合了铜促进的选择性三氟甲氧基化.该反应是可扩展的,可耐受各种官能团,并在温和的反应条件下区域选择性地进行.此外,机理研究表明,在反应过程中可能会生成cs [cu(ocf 3)2 ]中间体.
Doi:10.1002/anie.201901447

专利信息

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-4157344-A
优先权日:1978-01-16
标题 :Preparation of aryl trifluoromethyl ethers
发明人：FEIRING ANDREW E
权利人:DU PONT
摘要:A one-step process for the synthesis of aryl trifluoromethyl ethers by reacting phenol or certain substituted phenols with a perhalomethane and hydrogen fluoride is provided. The compounds produced by the process of this invention are useful intermediates in the production of dyestuffs and pharmaceuticals.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-11279687-B2
优先权日:2010-09-03
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; YUEN PO-WAI
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.