CAS: 23089-26-1; (S)-6-Methyl-2-((S)-4-Methylcyclohex-3-En-1-yl)Hept-5-En-2-Ol

该化合物是一种自然产生的单环松醇,主要存在于各种植物,特别是甘菊花的基本油类中,其特征是花粉芳香,经常用于化妆和香味工业,以保持其气味和皮肤对皮的特性.化学成分为,(-)-Bisabolol,其分子配方为C15H26O,其特征为助产其对应形式的手工业中心.该化合物展示了抗炎,抗微生物和抗氧化剂活动,使其在制药和治疗用途中具有价值.其低毒性和皮肤兼容性进一步提高了个人护理配方的吸引力.(-)-Bisabool在室内温度下一般没有色色,在相对高的沸点上,表明其稳定性.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

methanol (2R,3R,4S,5R,6S)-2-methyl-6-{[(2S)-6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-yl]oxy}tetrahydro-2H-pyran-3,4,5-triol (4S,8R)-8,9-Epoxy-p-menth-1-ene (S)-4-Isopropenyl-1-methylcyclohexene 7,8-epoxide α-bisabolol oxide B 2-(1-hydroxy-1-methylethyl)-5-methyl-5-(1-methylcyclohex-1-en-4-yl)tetrahydrofuran tetrahydro-α-bisabolol (6R,1'S)-epi-hernandulcin

合成工艺路线路线简述

    3-[(1S)-4-Methylcyclohex-3-En-1-Yl]But-3-En-1-Ol置于吡啶,Copper(I) Bromide Dimethylsulfide Complex,过氧化氢异丙苯,Chiral (D)-Hydroxamic Acid,三异丙氧基氧化钒体系中,用 四氢呋喃,氯仿,甲苯 用作溶剂,化学反应生成没药醇
    参考文献:均烯丙基醇的不对称环氧化及其在简明的全合成(-)-α-Bisabolol和(-)-8-Epi-α-Bisabolol中的应用.
    标题:均烯丙基醇的不对称环氧化及其在简明的全合成(-)-α-Bisabolol和(-)-8-Epi-α-Bisabolol中的应用.
    摘要:
    Doi:10.1002/anie.200390250

    海关参考信息

    专利信息


    专利号:US-7598291-B2
    优先权日:2004-09-02
    标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
    发明人:NIMNI MARCEL; HAN BO
    权利人:NIMNI MARCEL; HAN BO
    摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

    专利号:US-2010160244-A1
    优先权日:2004-09-02
    标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
    发明人:NIMNI MARCEL; HAN BO
    权利人:NIMNI MARCEL; HAN BO
    摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

    专利号:US-11547655-B2
    优先权日:2017-08-02
    标 题:Use of an extract of the pericarp of Nephelium lappaceum for hydrating the skin and/or mucous membranes
    发明人:BONNET ISABELLE; CADAU SÉBASTIEN; DANOUS LOUIS; DERCEVILLE CHARLOTTE; LEOTY-OKOMBI SABRINA
    权利人:BASF BEAUTY CARE SOLUTIONS FRANCE S A S
    摘要:A subject of the present invention is the cosmetic use of a pericarp extract of the plant Nephelium lappaceum for maintaining and/or increasing the hydration and/or the barrier effect of the skin and/or of the mucous membranes. The pericarp extract increases involucrin synthesis and the hyaluronic acid content and the synthesis of ATP and of the taurine transporter TAUT. Another subject of the invention relates to a cosmetic care process comprising the topical application of the pericarp extract of N. lappaceum. Finally, a subject of the invention relates to the pericarp extract for use, in particular dermatological use, thereof in the treatment and/or prevention of pathological conditions caused by a state of abnormal dryness of the skin and/or of the mucous membranes.

    专利号:US-9757317-B2
    优先权日:2014-09-12
    标题 :Cosmetic compositions and methods for inhibiting melanin synthesis
    发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR
    权利人:PROCTER & GAMBLE
    摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

    专利号:US-2012094919-A1
    优先权日:2009-03-16
    标题 :Use of tripeptides
    发明人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
    权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
    摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.

    专利号:US-9498420-B2
    优先权日:2013-05-01
    标 题:Cosmetic compositions and methods for inhibiting melanin synthesis
    发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; TANAKA SHUHEI
    权利人:PROCTER & GAMBLE
    摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
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    主要参考文献


    1: Arenberger P, Arenbergerová M, Drozenová H, Hladíková M, Holcová S. Effect of topical heparin and levomenol on atopic dermatitis: a randomized four-arm, placebo-controlled, double-blind clinical study. J Eur Acad Dermatol Venereol. 2011 Jun;25(6):688-94. doi: 10.1111/j.1468-3083.2010.03950.x. Epub 2011 Jan 9. German. Erratum in: Microb Cell Fact. 2017 Jan 31;16(1):19.
    5: Karami A, Dehghan-Mashtani N. Composition of the essential oil of Stachys benthamiana Boiss. from the south of Iran. Nat Prod Res. 2015;29(15):1473-6. doi: 10.1080/14786419.2014.1003185. Epub 2015 Jan 21. doi: 10.1007/s00403-014-1528-9. Epub 2015 Jan 4. doi: 10.1016/j.exppara.2014.10.001. Epub 2014 Nov 5. doi: 10.1016/j.neuroscience.2015.08.019. Epub 2015 Aug 15. doi: 10.1021/np5008697. Epub 2015 Jun 15. doi: 10.3390/molecules200711765. doi: 10.1111/ics.12339. Epub 2016 Jun 2. doi: 10.1021/acs.jnatprod.6b00740. Epub 2016 Sep 12. doi: 10.1159/000439351. Epub 2015 Sep 19.
    15: Sampaio TL, Menezes RR, da Costa MF, Meneses GC, Arrieta MC, Chaves Filho AJ, de Morais GB, Libório AB, Alves RS, Evangelista JS, Martins AM. Nephroprotective effects of (-)-α-bisabolol against ischemic-reperfusion acute kidney injury. Phytomedicine. 2016 Dec 15;23(14):1843-1852. doi: 10.1016/j.phymed.2016.11.008. Epub 2016 Nov 11. doi: 10.1016/j.jep.2016.06.022. Epub 2016 Jun 9. doi: 10.1007/s10495-016-1257-y. doi: 10.1016/j.talanta.2016.08.032. Epub 2016 Aug 10. doi: 10.1097/01.ASW.0000470155.29821.ed. doi: 10.1016/j.exppara.2016.09.018. Epub 2016 Sep 28.

    合成参考文献


    参考文献:10.1016/j.fct.2011.06.076
    摘要:Kim S, Jung E, Kim JH, Park YH, Lee J, Park D. Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. Food Chem Toxicol. 2011 Oct;49(10):2580–5. doi: 10.1016/j.fct.2011.06.076.
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