Ethyl 2-Phenylsulfinyl-E-2-Hexenoate置于potassium Carbonate体系中,用 Xylene 用作溶剂,化学反应 1.0H,以61%的收率获得山梨酸乙酯 参考文献:The Simple Synthesis Of Ethyl 2,4-Dienoates From Aldehydes And Ethyl 2-Phenylsulfinylacetate 标题:The Simple Synthesis Of Ethyl 2,4-Dienoates From Aldehydes And Ethyl 2-Phenylsulfinylacetate 摘要:醛类和乙基2-苯基亚磺酸乙酸酯(1)在哌啶存在下处理,生成2-苯基亚磺酸-2-烯基乙酸酯(z-2)的z-异构体.Z-2的热分解产生乙基e,E-2,4-二烯酸酯(3). Doi:10.1246/cl.1980.781
专利号:US-8735391-B2 优先权日:2008-09-26 标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods 发明人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J 权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS 摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
专利号:US-2025223247-A1 优先权日:2022-05-03 标 题:Process for the hydrogenation of unsaturated esters 发明人:GRAINGER DAMIAN; VAJARIA KRISHA 权利人:JOHNSON MATTHEY PLC 摘要:Some embodiments relate to a process for the hydrogenation of ester-containing substrates. More specifically, the embodiments relate to a process for the reduction of α,β-γ,δunsaturated containing esters and β,γ unsaturated containing esters of Formula (I) to produce an alcohol of Formula (II). The process of the embodiments uses a base, the conjugate acid of the base has a pKa of from 4 to 15. The process of the embodiments finds use in the synthesis of organic molecules.
专利号:US-9108940-B2 优先权日:2010-08-19 标题:Conversion of 5-(chloromethyl)-2-furaldehyde into 5-methyl-2-furoic acid and derivatives thereof 发明人:MIKOCHIK PETER; CAHANA AVIAD 权利人:MIKOCHIK PETER; CAHANA AVIAD; XF TECHNOLOGIES INC 摘要:The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharmaceutical, food, and fragrance molecules; as well as fuel or fuel additives.
专利号:CN-106086095-A 优先权日:2016-08-26 标题:A method of enzymatically catalyzing the synthesis of sorbic acid ester
专利号:CN-109251260-A 优先权日:2018-10-24 标题 :A living polymerization system for the synthesis of ultra-high molecular weight polymers based on phosphine base catalysis
专利号:WO-2010037050-A2 优先权日:2008-09-26 标 题:Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods
[参考文献]: Balasubramanian Narasimhan, Et Al. Quantitative Structure-Activity Relationship Studies For Prediction Of Antimicrobial Activity Of Synthesized 2,4-Hexadienoic Acid Derivatives. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5836-45.
合成参考文献
参考文献:10.1021/jo0163400 摘要:Garaas SD, Hunter TJ, O'Doherty GA. An enantioselective synthesis of tarchonanthuslactone. J Org Chem. 2002 Apr 19;67(8):2682–5. doi: 10.1021/jo0163400.