CAS: 2476-37-1; 2',5'-Dichloroacetophenone

上下游产品

methyl magnesium iodide 2,5-dichlorobenzonitrile para-dichlorobenzene acetyl chloride 4-[(2,5-dichloro-phenyl)-thioacetyl]-morpholine 2-(2,5-dichloro-phenyl)-propan-2-ol 1-(2,5-dichlorophenyl)ethanol 1-(2,5-dichlorophenyl)-3-phenylprop-2-en-1-one

2,5-二氯苯甲酸置于1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,N,N-二异丙基乙胺体系中,用 乙醚,二氯甲烷 用作溶剂,化学反应 2.0H,反应生成2,5-二氯苯乙酮
参考文献: Anti-Hcmv Compositions And Methods[fr] Compositions Anti-Hcmv Et Procédés
标题: Anti-Hcmv Compositions And Methods[fr] Compositions Anti-Hcmv Et Procédés

专利信息

专利号:WO-9910310-A1
优先权日:1997-08-29
标 题:Process for producing diphenylethers and esters
发明人：LOURENS GERHARDUS JOHANNES
权利人:DOW CHEMICAL CO
摘要:An improved synthesis of diphenylethers, and in particular, the bacteriostat 2,4,4'-trichloro-2'-hydroxydiphenylether, is described wherein 2'-acetyl-2,4,4'-trichlorodiphenylether is oxidised under Baeyer-Villiger conditions to produce 2'-acetoxy-2,4,4'-trichlorodiphenylether in near quantitative yield. Best oxidative conditions include the use of anhydrous permaleic acid produced in situ. The ester is purified readily by simple recrystallization, as no dibenzofurans and only minor amounts of byproducts are formed in the process. The ester is converted into the desired halogenated phenolic diphenylether, 2,4,4'-trichloro-2'-hydroxydiphenylether, by hydrolysis or transesterification. The final product is purified to a high degree by vacuum distillation and crystallization to meet current purity standards for approved applications.

专利号:US-2025188083-A1
优先权日:2021-06-25
标 题:Modulators of Histone Acetyltransferase 1 and Methods of Treatment Thereof
发明人：GRUBER JOSHUA JAMES; LIPCHIK ANDREW; SNYDER MICHAEL P; SCHOW STEVEN R
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Small molecules compounds and methods of their synthesis are provided. Small molecules identified can inhibit histone acetyltransferase 1 activity. Formulations and medicaments are also provided that are directed to the treatment of human disorders and conditions, such as, for example, neoplasms, cancers, viral, fungal, and parasitic infections, and aging. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

专利号:RU-2193549-C2
优先权日:1997-02-05
标 题 :Method of synthesis of halide-substituted compounds of hydroxybiphenyl

专利号:US-10072009-B2
优先权日:2014-10-21
标 题 :N-substituted beta-carbolinium compounds as potent P-glycoprotein inducers
发明人：BHARATE SANDIP; KUMAR AJAY; MANDA SUDHAKAR; JOSHI PRASHANT; BHARATE SONALI; VISHWAKARMA RAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R 1 and R 2 groups are selected from halogens or trifluoromethyl; R 3 group is selected from hydrogen or methyl; Ar is selected from aryl and heteroaryl, X is selected from halogens; and R 1 and R 2 groups may be attached to any position on ring E. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the N-substituted beta-carbolinium compounds. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.

专利号:US-5734067-A
优先权日:1994-09-28
标题 :Anti-oxidative tricyclic, condensed heterocyclic compound
发明人：JINNO SHUJI; KOGURE YASUYO; ONUKI HIROYUKI; OKITA TAKAAKI
权利人:NIPPON SUISAN KAISHA LTD
摘要:Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH 2 --Câ•?O, CH 2 --CH 2 or CHâ•?CH; Z represents O, S, or Sâ•?O; R 1 to R 8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF 3 ; and at least two of R 1 to R 4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of α-tocopherol, so the compound is promising as a therapeutic drug for a variety of diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may b involved.

专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.