CAS: 33657-49-7; Chloromethylbutyrate

相似化合物

77877-95-3 77877-94-2 66542-51-6

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CAS号49715-04-0 氯甲基氯磺酸酯 | CAS号107-92-6 正丁酸 | CAS号50-00-0 甲醛 | CAS号141-75-3 丁酰氯 | CAS号593-71-5 氯碘甲烷 | CAS号156-54-7 丁酸钠 | CAS号2472-88-0 四丁基硫酸铵 | CAS号623-42-7 丁酸甲酯 | CAS号554-68-7 三乙胺盐酸盐 | CAS号66542-37-8 (5-fluoro-2,4-d... | CAS号80418-47-9 chloromethyl 2-... | CAS号80418-48-0 chloromethyl 3-... | CAS号80418-49-1 chloromethyl 4-...

氯甲基氯磺酸酯,丁酸置于四丁基硫酸氢铵,Potassium Carbonate体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 4.0H,以58%的收率获得产物丁酸氯甲酯
参考文献:滨海嗜热菌中乙酰酯酶狭窄底物特异性的结构基础.
标题:滨海嗜热菌中乙酰酯酶狭窄底物特异性的结构基础.
摘要:来自碳水化合物酯酶家族7的乙酰基酯酶表现出不同寻常的底物特异性.这些蛋白质可高效催化不同的乙酸酯的裂解,但对较大的酰基无反应性.这种独特的选择性分布的结构基础是未知的.在这里,我们使用进化关系,结构信息,荧光动力学测量和定点诱变研究了来自滨海嗜热菌的热稳定乙酰酯酶(tm0077).我们使用了一系列的小分子酶底物,包括新型的荧光酯,测量了这一特异性的动力学和结构决定因素.这些实验确定了亲核丝氨酸周围的两个疏水可塑性残基(pro228和ile276),这些残基赋予tm0077对小的,直链酯.这些残基被丙氨酸取代后,Tm0077具有更广泛的特异性,可以水解更长和更大的酯.我们的结果表明,乙酰酯酶的特异性已经通过进化来微调,以催化从各种底物中去除乙酸酯基团,但是可以通过聚焦氨基酸取代进行修饰,以产生能够裂解更大酯官能团的酶.
DOI:10.1016/j.Bbapap.2012.05.009

专利信息

专利号:WO-2011130852-A1
优先权日:2010-04-21
标题:Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers
发明人：SOUZA FABIO; PAN MING
权利人:ALPHORA RES INC; SOUZA FABIO; PAN MING
摘要:4- (2,3- dichlorophenyl) -1,4- dihydro- 2,6- dimethyl- 5- methoxycarbonyl- 3- pyridinecarboxylic acid, a key intermediate in the synthesis of the cardiovascular calcium channel blocker drug 3-butanoyloxymethoxycarbonyl-5- methoxycarbonyl-4- (2,3-dichlorophenyl) -2,6- dimethyl-1,4- dihydropyridine, of purity greater than 97% and essentially free of the corresponding diacid, is prepared by a process involving selective precipitation of its carboxylate via addition of concentrated solutions of alkali metal salts. Similar intermediate mono-carboxylic acids useful in the synthesis of other unsymmetrically substituted dihydropyrine drugs such as nisoldipine, nitrendipine and nimodipine can be similarly prepared and purified.

专利号:US-8455655-B2
优先权日:2010-05-07
标题:Preparation of dihydropyridines
发明人：VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH
权利人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH; LESVI LABORATORIOS SL
摘要:The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.

专利号:US-3929840-A
优先权日:1972-07-14
标题 :Labile esters of ({31 )(cis-1,2-epoxypropyl)phosphonic
发明人：CHRISTENSEN BURTON G; LEANZA WILLIAM J; ALBERS-SCHONBERG GEORG
权利人:MERCK & CO INC
摘要:Labile esters of (-)(cis-1,2-epoxypropyl)phosphonic acid are prepared from the free acid or salts thereof by reaction with an alcohol or a hydrocarbyl halide. In addition to their utility as intermediates in the synthesis of antibacterially active salts of (-)(cis-1,2-epoxypropyl)phosphonic acid, those esters have significant antibacterial activity.

专利号:US-9907796-B2
优先权日:2012-10-04
标题:Methods of treating tumoral diseases, or bacterial or viral infections
发明人：DEOKAR RHUSHIKESH CHANDRABHAN; DUGAR SUNDEEP; MAHAJAN DINESH; WERNER MILTON HENRY
权利人:DEOKAR RHUSHIKESH CHANDRABHAN; DUGAR SUNDEEP; MAHAJAN DINESH; WERNER MILTON HENRY; INHIBIKASE THERAPEUTICS INC
摘要:Novel compounds and their synthesis are described. Methods for using these compounds in the prevention or treatment of cancer, a bacterial infection or a viral infection in a subject are also described.

专利号:US-9359376-B2
优先权日:2011-04-08
标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

专利号:US-9802975-B2
优先权日:2014-06-10
标题:Protecting groups for “Z nucleotide†and methods thereof
发明人：LUNSTAD BENJAMIN D; DELLINGER DOUGLAS J
权利人:AGILENT TECHNOLOGIES INC
摘要:The present disclosure provides nucleoside compounds and oligonucleotides including an unnatural 6-amino-2-pyridone heterocyclic base where the 6-amino and 2-positions are protected. The 2-position of the heterocyclic base can be protected with an acyl-oxy-methyl protecting group. In some embodiments, the protected heterocyclic base has the following structure where AcOM is an acetyl-oxy-methyl group and R is a ribose or deoxyribose sugar: n n n n n n n n n n Methods for synthesizing an oligonucleotide are provided in which the subject compounds find use. The method can include protecting an unnatural (e.g., Z) nucleotide with an acetyl-oxy-methyl group; incorporating the protected unnatural nucleotide into a nucleotide sequence on a solid support; and removing the acetyl-oxy-methyl group from the unnatural nucleotide incorporated into the nucleotide sequence. The compounds and methods find use in the synthesis of long oligonucleotides including Z nucleotides.