专利号:WO-9925385-A1 优先权日:1997-11-17 标 题:A method of increasing nucleic acid synthesis with ultrasound 发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID 权利人:IMARX PHARMACEUTICAL CORP 摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.
专利号:US-8772301-B2 优先权日:2009-12-18 标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof 发明人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D 权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
专利号:US-2016186217-A1 优先权日:2013-06-13 标 题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation
专利号:US-2003113805-A1 优先权日:1995-07-22 标 题:Intrinsically labelled solid support 发明人:MAIN BRIAN GEOFFREY; SHUTE RICHARD EDEN 权利人:ZENECA LTD A LONDON CORP 摘要:A compound library comprises a plurality of different units each comprising a solid support with which is associated a single member of the compound library, each solid support has a defined chemical composition which acts as an intrinsic label capable of identifying the first choice in the synthesis of the associated member of the compound library.
专利号:IT-SA20120007-A1 优先权日:2012-05-16 标题 :SYNTHESIS OF POLIALCHILSOLFONATI TO BE INTENDED FOR THE PRODUCTION OF IONOMERS AND POLYELETTROLITES BY SELECTIVE SULFONATION OF POLYDIENES AND COPOLYMERS OF CONJUGATED DIENS.
专利号:CN-115403494-A 优先权日:2022-06-09 标题 :A method for the synthesis of β-hydroxysulfone derivatives by oxygen-initiated difunctionalization of alkenes under mild conditions
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