CAS: 75-97-8; 3,3-Dimethyl-2-Butanone

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CAS号917-92-0 3,3-二甲基-1-丁炔 | CAS号464-07-3 3,3-二甲基-2-丁醇 | CAS号563-79-1 2,3-二甲基-2-丁烯 | CAS号7664-93-9 硫酸 | CAS号76-09-5 频哪醇 | CAS号5076-20-0 2,3-二甲基-2,3-环氧丁烷 | CAS号39263-43-9 3,3-dimethyl-bu... | CAS号451-40-1 二苯乙酮 | CAS号39199-12-7 3,3-dimethyl-1-... | CAS号107047-18-7 N-(3,3-dimethyl... | CAS号106596-69-4 2,4,4-trimethyl... | CAS号105602-69-5 6,6,7,7,8,8,9,9... | CAS号104940-88-7 4,4-dimethyl-2-... | CAS号1048668-70-7 AZD8329 | CAS号606-23-5 1,3-茚满二酮 | CAS号55107-14-7 新戊酰基乙酸甲酯 | CAS号540-88-5 醋酸叔丁酯 | CAS号598-98-1 特戊酸甲酯 | CAS号5469-26-1 1-溴频哪酮

频哪醇置于盐酸,水体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 频哪酮
参考文献:抗衡阴离子直接参与糖苷酸水解†
标题:抗衡阴离子直接参与糖苷酸水解†
摘要:自19世纪末以来,研发了糖苷酸水解的机理,并伴随着许多有关该机理的文献发表,尽管令人惊讶的是很少有人关注酸的抗衡阴离子的作用.本文研究了酸的抗衡阴离子是否直接参与糖苷,甲基α-和β-D-D-吡喃葡萄糖苷(mgp)的酸水解.水,74%的水溶液和82%的1,4-二恶烷体系.由于反应系统的质子活度是公认机制中重要的决定速率的参数,因此在本研究中已对其进行了仔细的估计.结果表明,溴阴离子直接参与水溶剂体系中mgp的酸水解反应,而溴阴离子在74%和82%的水溶液中的参与进一步明显.1,4-二恶烷溶剂系统.还建议氯离子直接参与这些二恶烷 溶剂系统.
DOI:10.1039/c2Ob25451D

专利信息

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:US-4751312-A
优先权日:1984-07-20
标 题:Process and intermediates for the synthesis of diastereomeric compounds
发明人：GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF
权利人:BAYER AG
摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).

专利号:EP-1709057-B1
优先权日:2004-01-21
标 题:Synthesis of spongosine
发明人：OUZMAN JACQUELINE VALERIE ANNE
权利人:CAMBRIDGE BIOTECHNOLOGY LTD
摘要:Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with 2-methoxyadenine to form 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine, then deprotection of the 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine to form spongosine is described. Synthesis of intermediates for use in the synthesis of spongosine is also described.

专利号:US-8742028-B2
优先权日:2009-05-06
标 题:Solid support for Fmoc-solid phase synthesis of peptide acids
发明人：SRIVASTAVA KRIPA S; DAVIS MATTHEW R
权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC
摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.

专利号:US-8420848-B2
优先权日:2009-01-09
标题:Process for the synthesis of beta glycerol phosphate
发明人：KULKARNI YASHWANT
权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC
摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.