CAS: 78649-41-9; N1,N3-Bis(2,3-Dihydroxypropyl)-5-(2-Hydroxy-N-Methylacetamido)-2,4,6-Triiodoisophthalamide

上下游产品

5-aminoisophthalic acid 5-methylaminoisophthalic acid dimethyl ester 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide 5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide

5-[[2-(乙酰氧基)乙酰基]氨基]-2,4,6-三碘-1,3-苯二甲酰氯置于水,三乙胺,Sodium Hydroxide体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 23.0H,反应生成 碘美普尔
参考文献:조영제 중간체의 신규 제조방법 및 이를 이용한 조영제의 제조방법
标题:조영제 중간체의 신규 제조방법 및 이를 이용한 조영제의 제조방법
摘要:本发明的制造方法通过简化造影剂的中间体或造影剂制造过程,减少废溶剂的反应生成,环保性强,并且可以显著降低制造成本.因此,本发明的制造方法可以大幅降低造影剂的生产成本,经济实惠,适合大规模生产.

专利信息

专利号:US-9157156-B2
优先权日:2009-07-07
标题 :Process for the preparation of a iodinating agent
发明人：ANELLI PIER LUCIO; VISCARDI CARLO FELICE; DELOGU PIETRO; GOFFREDI FABRIZIO; NARDELLI ALFONSO; GIOVENZANA GIOVANNI BATTISTA
权利人:ANELLI PIER LUCIO; VISCARDI CARLO FELICE; DELOGU PIETRO; GOFFREDI FABRIZIO; NARDELLI ALFONSO; GIOVENZANA GIOVANNI BATTISTA; BRACCO IMAGING SPA
摘要:The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-10836711-B2
优先权日:2017-02-10
标 题 :Method for the one-pot production of organo-iodinated compounds
发明人：PETTA MYRIAM; PELLINGHELLI STEPHAN
权利人:GUERBET SA
摘要:The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.

专利号:US-12269790-B1
优先权日:2022-04-29
标题:Process for the preparation of 2,4,6-triiodophenol derivatives
发明人：BARANYAI ZSOLT; GUIDOLIN NICOL; LAZZARI FEDERICA; UGGERI FULVIO
权利人:BRACCO IMAGING SPA
摘要:The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I 2 and an oxide or a salt of an element of group 11 of the periodic table.

专利号:US-10836710-B2
优先权日:2016-12-05
标 题 :Mechanochemical synthesis of radiographic agents intermediates
发明人：BARGE ALESSANDRO; BARICCO FRANCESCA; CRAVOTTO GIANCARLO; FRETTA ROBERTA; LATTUADA LUCIANO
权利人:BRACCO IMAGING SPA
摘要:The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.

专利号:US-9382194-B2
优先权日:2011-10-31
标 题:Iodination process for the preparation of 3, 5-disubstituted-2, 4, 6-triiodo aromatic amines compounds
发明人：XING HONGDENG; LI LEI; HU ZHIQI
权利人:XING HONGDENG; LI LEI; HU ZHIQI; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:The invention discloses a improved process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein R 1 and R 2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.