CAS: 1484-26-0; 3-Benzyloxyaniline

相似化合物

24318-00-1 57181-90-5 6373-46-2

上下游产品

3-(benzyloxy)nitrobenzol N-(3-(benzyloxy)phenyl)acetamide 1-(benzyloxy)-2-chlorobenzene 3-azidophenyl benzyl ether 3-Benzyloxytrifluoromethanesulfonanilid 2-(3-Benzyloxy-phenylamino)-6-chloro-3-nitro-benzoic acid 3-(benzyloxy)-4-bromoaniline 5-(Benzyloxy)-2-bromophenylamine

间硝基苯酚置于potassium Carbonate,一水合肼体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应生成3-苄氧基苯胺
参考文献:具有抗凝活性的p1处带有4-(piperidin-1-Yl)吡啶的直接凝血酶抑制剂的合成及生物学评价
标题:具有抗凝活性的p1处带有4-(piperidin-1-Yl)吡啶的直接凝血酶抑制剂的合成及生物学评价
摘要:描述了一种新型的非肽类直接凝血酶抑制剂的设计和合成,该抑制剂建立在1-(吡啶-4-基)哌啶-4-羧酰胺的结构上.从显示弱的凝血酶(fiia)和xa因子(fxa)抑制活性的强碱性1-Ami基哌啶衍生物(6)开始,通过优化碱性p1和x-取代的苯基p4可显着提高抗fiia活性和人工膜通透性结合部分.结构-活性关系研究以及有用的分子建模结果使我们得以鉴定出化合物13B,该化合物表现出出色的fiia抑制作用(k I = 6 Nm),抗xa活性弱(k I= 5.64μm),并且对其他丝氨酸蛋白酶(例如胰蛋白酶)具有显着的选择性.化合物13B在低微摩尔范围内显示出体外抗凝活性,并具有显着的膜通透性.在小鼠中(离体),13B在口服给药(100 Mg.kg-1)后2 H表现出抗凝作用,与对照组相比,活化的部分凝血活酶时间(aptt)延长了43%(p <0.05).
Doi:10.1021/jm401169A

专利信息

专利号:US-2024097109-A1
优先权日:2021-02-11
标 题:Bottom-Up, Scalable Synthesis Of Oxide-Based Sub-Nano And Nanofilaments And Nanofilament-Based Two-Dimensional Flakes And Mesoporous Powders
发明人：BARSOUM MICHEL W; BADR HUSSEIN OSAMA
权利人:UNIV DREXEL
摘要:Provided are methods to convert—through a bottom-up approach—binary and ternary titanium carbides, nitrides, borides, phosphides, aluminides, and silicides into lepidocrocitic nanofilaments that in some cases self-assemble into 2D flakes by immersing them in a quaternary ammonium solution at moderate temperatures. The resulting flakes can comprise nanofilaments in cross-section, some of which nanofilaments can be few microns long in some instances.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-8076332-B2
优先权日:2006-12-26
标 题:N- (2-aminophenyl) benzamide derivative having urea structure
发明人：MOGI HIROYUKI; TAJIMA HISASHI; MISHINA NORIKO; YAMAZAKI YUSUKE; YONEDA SHINJI; WATANABE KATSUHIKO; FUJIKAWA JUNKO; YAMAMOTO MINORU
权利人:MOGI HIROYUKI; TAJIMA HISASHI; MISHINA NORIKO; YAMAZAKI YUSUKE; YONEDA SHINJI; WATANABE KATSUHIKO; FUJIKAWA JUNKO; YAMAMOTO MINORU; SANTEN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a study on the synthesis of a novel N-(2-aminophenyl)benzamide derivative having an urea structure and represented by the general formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork cells and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pressure. In the formula, R 1 and R 2 represent a hydrogen atom, a lower alkyl group, or the like; R 3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, or the like; R 4 and R 5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, or the like; X represents a lower alkylene group or the like; Y represents a single bond, a lower alkylene group, or the like; l and m represent 0, 1, 2, or the like.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:US-5874443-A
优先权日:1995-10-19
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.