CAS: 15950-66-0; 2,3,4-Trichlorophenol

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CAS号54135-80-7 2,3,4-三氯苯甲醚 | CAS号858013-84-0 toluene-4-sulfo... | CAS号288-32-4 咪唑 | CAS号61925-89-1 2,3,4-Trichloro... | CAS号634-67-3 2,3,4-三氯苯胺 | CAS号95-77-2 3,4-二氯苯酚 | CAS号13297-01-3 2,4-二氨基-3-氯苯酚 | CAS号634-66-2 1,2,3,4-四氯苯 | CAS号15944-74-8 3,6-dichloro-2-... | CAS号58-90-2 砷原子吸收标样 | CAS号492-88-6 3-乙氧基水杨醛 | CAS号507-70-0 2-茨醇；冰片；龙胆 | CAS号95-57-8 邻氯苯酚 | CAS号106-48-9 对氯苯酚 | CAS号120-83-2 2,4-二氯苯酚 | CAS号108-95-2 苯酚 | CAS号25141-27-9 (2,3,4-TRICHLOR... | CAS号132-64-9 氧芴 | CAS号54135-80-7 2,3,4-三氯苯甲醚 | CAS号57117-31-4 2,3,4,7,8-五氯二苯并呋喃

1,2,3,4-四氯苯置于氢溴酸,Sodium Methylate体系中,化学反应生成三氯酚
参考文献:Holleman,Recueil Des Travaux Chimiques Des Pays-Bas,1920,Vol. 39,P. 748
标题:Holleman,Recueil Des Travaux Chimiques Des Pays-Bas,1920,Vol. 39,P. 748

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-7696389-B2
优先权日:2006-03-24
标 题 :Method for reducing microcontaminants during synthesis of pentachlorophenol
发明人：SAVAGE PHILLIP E; YU JIANLI
权利人:UNIV MICHIGAN
摘要:A method for reducing contaminants during synthesis of pentachlorophenol includes providing a phenol-based starting material and a catalyst, which form a reaction mixture. A chlorine flow is introduced so that it is in contact with the reaction mixture, and the starting material and chlorine are reacted via a temperature-programmed reaction. The chlorine flow is terminated at a predetermined temperature prior to an end of the temperature-programmed reaction and/or at a point where the yield of pentachlorophenol is less than about 95%.

专利号:WO-9845231-A1
优先权日:1997-04-09
标题:Supports for solid phase synthesis
发明人：SHAO HUI; CASTELHANO ARLINDO L
权利人:CADUS PHARMACEUTICAL CORP
摘要:Supports for solid-phase synthesis are disclosed. The supports include a phenol or thiophenol linker moiety. A substrate compound can be immobilized to the support through the linker moiety. The supports are suitable for combinatorial synthesis, including synthesis of combinatorial libraries.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5115099-A
优先权日:1988-06-14
标 题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
发明人：KUROIWA KATSUMASA; MATSUURA HITOSHI; KATAYAMA KATSUHIRO; NAKATSUYAMA SHUICHI; NAGASAWA TAKESHI; ENDO KOJI
权利人:NITTO BOSEKI CO LTD
摘要:Novel compounds represented by the following formula: ##STR1## wherein A represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides by a novel process comprising a selective deprotection step whereby the protecting group on the α-amine group of arginine is removed in the presence of a hydrochloric acid, acetic acid and dimethylformamide mixture, but a tert-alkyl protecting group on the --COOH group of the nitroanilide ring is not removed by this step.