专利号:US-9862745-B2 优先权日:2004-03-30 标题 :Synthesis of boronic ester and acid compounds 发明人:AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER 权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC 摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
专利号:EP-1582527-A1 优先权日:2004-03-31 标题:Synthesis of phosphorus based ligands 发明人:BERENS ULRICH 权利人:CIBA SC HOLDING AG 摘要:Chiral ligands of the formula I or II, may be obtained in high enantiomeric purity from compounds of the formulae III or IV, respectively, with suitable phosphines, where the symbols R1, R, n, R3, R4, R' are as described in claim 1. The products may be converted into transition metal complexes which are useful as catalysts for asymmetric hydrogenation reactions.
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