2-甲基吡啶氧化物置于硫酸,硝酸,铁粉,溶剂黄146体系中,化学反应生成2-甲基-4-氨基吡啶 参考文献:Den Hertog Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1951,Vol. 70,P. 591,598 标题:Den Hertog Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1951,Vol. 70,P. 591,598
专利号:WO-2025030970-A1 优先权日:2023-08-04 标 题:Condensing agent and use thereof in preparation of isothiocyanate 发明人:SI XIAOJIA; CHEN QUAN; LEI AIWEN; YI HONG; CHEN YI-HUNG 权利人:HUAWEI TECH CO LTD 摘要:The present application relates to the field of organic synthesis. Provided is a condensing agent. The condensing agent has formula 1, wherein R1 and R2 are each independently selected from the same or different electron-withdrawing groups. Compared with thiophosgene or carbon disulfide used in a traditional solution, the condensing agent provided in the embodiments of the present application has lower toxicity, and the condensing agent is a solid, such that the diffusion of pollution is easily controlled. Therefore, the condensing agent provided in the embodiments of the present application can be used for environmentally friendly synthesis of an isothiocyanate compound and has relatively small influence on the environment. Moreover, the condensing agent provided in the embodiments of the present application comprises electron-withdrawing groups, such that the yield of the isothiocyanate compound can be increased.
专利号:US-9751851-B2 优先权日:2013-09-20 标 题:Molecules and compositions that inhibit gram negative bacteria and their uses 发明人:BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T 权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T 摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.
专利号:EP-3070087-B1 优先权日:2011-08-05 标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors
专利号:TW-572896-B 优先权日:2000-05-26 标 题:Process for the synthesis of amine ethers from secondary amino oxides
专利号:US-2004180938-A1 优先权日:2001-07-03 标题 :Novel butadiene derivatives, process for preparation of the same and intermediates for the synthesis thereof 发明人:OHTANI AKIO; OGIKU TSUYOSHI; YAMADA YASUHIRO 摘要:A butadiene derivative having an excellent inhibitory activity on the PAI-1, which is represented by the general formula [I]: n n n wherein R 1 is a hydrogen atom or a lower alkyl group, R 2 is a lower alkyl group, R 3 is a lower alkoxy group, R 4 is a hydrogen atom or a lower alkyl group, R 5 is a lower alkyl group, or a pharmaceutically acceptable salt thereof, a process a process for preparing the same and an intermediate thereof.
专利号:EP-1403252-A1 优先权日:2001-07-03 标题 :Novel butadiene derivatives, process for preparation of the same and intermediates for the synthesis thereof